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Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.
Nat Metab
January 2025
Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Interoception broadly refers to awareness of one's internal milieu. Although the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferent signalling and corresponding brain circuits that shape perception of the viscera are not entirely clear. Here, we use mice to parse neural circuits subserving interoception of the heart and gut.
View Article and Find Full Text PDFSeparate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation.
Nat Metab
January 2025
Monell Chemical Senses Center, Philadelphia, PA, USA.
The hippocampus (HPC) has emerged as a critical player in the control of food intake, beyond its well-known role in memory. While previous studies have primarily associated the HPC with food intake inhibition, recent research suggests a role in appetitive processes. Here we identified spatially distinct neuronal populations within the dorsal HPC (dHPC) that respond to either fats or sugars, potent natural reinforcers that contribute to obesity development.
View Article and Find Full Text PDFDeciphering the safeguarding role of cysteine residues in p53 against HO-induced oxidation using high-resolution native mass spectrometry.
Commun Chem
January 2025
Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Manchester, UK.
The transcription factor p53 is exquisitely sensitive and selective to a broad variety of cellular environments. Several studies have reported that oxidative stress weakens the p53-DNA binding affinity for certain promoters depending on the oxidation mechanism. Despite this body of work, the precise mechanisms by which the physiologically relevant DNA-p53 tetramer complex senses cellular stresses caused by HO are still unknown.
View Article and Find Full Text PDFMolecular basis for the stepwise and faithful maturation of the 20 proteasome.
Sci Adv
January 2025
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
The proteasome degrades most superfluous and damaged proteins, and its decline is associated with many diseases. As the proteolytic unit, the 20 proteasome is assembled from 28 subunits assisted by chaperones PAC1/2/3/4 and POMP; then, it undergoes the maturation process, in which the proteolytic sites are activated and the assembly chaperones are cleared. However, mechanisms governing the maturation remain elusive.
View Article and Find Full Text PDFNeural correlates of olfactory working memory in the human brain.
Neuroimage
January 2025
Chemical Senses and Mental Health Lab, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:
Previous research has revealed that the insula, pallidum, thalamus, hippocampus, middle frontal gyrus, and supplementary motor area are activated during odor memory and that the performance of olfactory working memory is affected by the verbalization of odors. However, the neural mechanisms underlying olfactory working memory and the role of verbalization in olfactory working memory are not fully understood. Twenty-nine participants were enrolled in a study to complete olfactory and visual n-back tasks using high- and low-verbalizability stimuli while undergoing fMRI imaging.
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