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The role of serendipity in our investigation of embryo implantation.
Dev Biol
January 2025
Department of Cell Biology, University of Virginia Health System, PO Box 800732, Charlottesville, VA, 22908-0732, USA. Electronic address:
Serendipity plays a huge role in science, and having a prepared mind that can seize upon a chance observation or occurrence can drive a project forward. This happened in my lab with a project centered on the regulation of trophoblast cell behavior at implantation. We discovered that amino acids regulate the onset of trophoblast motility through the activation of the kinase complex mTORC1, and that this acts as a checkpoint to trophoblast differentiation.
View Article and Find Full Text PDFCasual detection of an abdominal aortic aneurysm thanks to a trainee-made ultrasound with two subsequent "domino" diagnoses: case report and insights on the role of ultrasound courses.
J Ultrasound
December 2024
Geriatrics Unit, Garibaldi-Nesima Hospital, Catania, Italy.
Early detection of abdominal aortic aneurysm (AAA) is crucial as untreated lesions can be life-threatening. We describe the case of a fortuitous ultrasound (US) detection of AAA by a trainee which allowed two subsequent "domino" diagnoses. A 69 y.
View Article and Find Full Text PDFNew specimens of Helicops boitata (Serpentes: Dipsadidae: Hydropsini), with data on morphological variation and behavior.
Zootaxa
July 2024
Programa de Pós-Graduação em Ecologia e Conservação da Biodiversidade; Instituto de Biociências; Universidade Federal de Mato Grosso; Av. Fernando Corrêa da Costa; 2367; 78060-900; Cuiabá; Mato Grosso; Brazil; Programa de Pós-Graduação em Zoologia; Instituto de Biociências; Universidade Federal de Mato Grosso; Brazil; Faculdade de Medicina Veterinária; Universidade Federal de Mato Grosso; Brazil.
We report data on morphological variation and behavior of the recently described watersnake Helicops boitata, previously known strictly from the holotype. Our data come from five new specimens fortuitously found in a private area near the type locality, in the Brazilian Pantanal wetlands. The expanded sample revealed polymorphism in at least two scalation features previously assumed as diagnostic of the species (i.
View Article and Find Full Text PDFInterstitial 11q deletion in a patient with Sprengel's deformity: a case report and review of the literature.
Mol Cytogenet
December 2024
Department of Genetics, Charles Nicolle Hospital, Tunis, Tunisia.
Article Synopsis
- The article discusses a rare genetic abnormality involving deletions on chromosome 11, specifically between the 11q13 and 11q23 regions, which can lead to various clinical features including intellectual disabilities and malformations, though these do not consistently correlate with specific genetic patterns.* -
- The case study focuses on a 9-year-old boy exhibiting Sprengel's deformity, iris and chorioretinal coloboma, and mild motor development delay, identified to have a significant interstitial deletion on chromosome 11 through advanced genetic testing methods.* -
- The findings emphasize the variability in symptoms associated with 11q deletions and suggest that the observed deformities might not have a direct genetic link but rather could be
Necrolytic migratory erythema: a fortuitous diagnosis.
BMJ Case Rep
November 2024
Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
A woman in her late 60s presented with widespread, itchy, dark lesions over her trunk and legs for 1 month. Initially, she was managed as nutritional dermatitis and experienced partial improvement. However, her condition worsened over 2 months, characterised by aggravated skin lesions, new-onset diabetes and a 12 kg weight loss.
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