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Sea-Island Micelle Structured Hydrogel Scaffold: A Dual-Action Approach to Combat Cartilage Damage under RA Conditions.
ACS Appl Mater Interfaces
January 2025
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Rheumatoid arthritis (RA) is a common autoimmune joint disease characterized by persistent synovial inflammation and cartilage damage. The current clinical treatments primarily utilize drugs such as triptolide (TP) to address inflammation, yet they are unable to directly repair damaged cartilage. Furthermore, the persistent inflammation often undermines the effectiveness of traditional cartilage repair strategies, preventing them from achieving optimal outcomes.
View Article and Find Full Text PDFRedox/NIR dual-responsive glutathione extended polyurethane urea electrospun membranes for synergistic chemo-photothermal therapy.
Int J Pharm
January 2025
Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, Palermo, Italy; Istituto per la Ricerca e Innovazione Biomedica (IRIB), CNR, Via Ugo La Malfa, 153, 90146, Palermo, Italy. Electronic address:
Despite advancements in cancer treatments, therapies frequently exhibit high cytotoxicity, and surgery remains the predominant method for treating most solid tumors, often with limited success in preventing post-surgical recurrence. Implantable biomaterials, designed to release drugs at a localised site in response to specific stimuli, represent a promising approach for enhancing tumour therapy. In this study, a redox-responsive glutathione extended polyurethane urea (PolyCEGS) was used to produce paclitaxel (PTX) and gold nanorods (AuNRs) loaded electrospun membranes for combined redox/near-infrared (NIR) light-responsive release chemotherapy and hyperthermic effect.
View Article and Find Full Text PDFA novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds.
Biomed Mater
November 2024
Department of Metallurgical and Materials Engineering, Indian Institute of Technology Ropar, Ropar, Punjab 140001, India.
Wound healing is a complex and dynamic process supported by several cellular events. Around 13 million individuals globally suffer from chronic wounds yearly, for which dressings with excellent antimicrobial activity and cell viability (>70%, as per ISO 10993) are needed. Excessive use of silver can cause cytotoxicity and has been linked to increasing antimicrobial resistance.
View Article and Find Full Text PDFAntibacterial Materials: Influence of the Type and Conditions of Biological Tests on the Measured Antibacterial Activity.
Macromol Rapid Commun
December 2024
Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire UMR 7273, Marseille, 13397, France.
In recent years, the growing problem of antibiotic resistance has highlighted the need for antibacterial materials to prevent the development of infections. Different types of tests exist to certify the antibacterial properties of materials. Variations in results can occur due to the unique requirements of each test technique.
View Article and Find Full Text PDFIncorporating an artificially synthesized fluoride complex into urethane-acrylate-based 3D printing resin: Effects on mechanical properties, cytotoxicity, antimicrobial actions, and its long-term fluoride-releasing properties.
J Dent
November 2024
Department of Prosthodontics, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address:
Objectives: To synthesize a 3D printing resin with antibacterial and long-term fluoride-releasing properties.
Methods: (4,4-Bis-4-[2‑hydroxy-3-(2-methacryloyloxy)propoxy]-phenyl-pentanol-amine)-N,N-diacetic acid zirconium (IV) fluoride complex was synthesized from 4,4-bis-(4-hydroxyphenyl)-pentanoic acid and monitored using proton nuclear magnetic resonance spectroscopy. The synthesized complex was incorporated into a urethane-acrylate-based (UA) resin at 5 wt% and 10 wt% (5F-UA and 10F-UA groups, respectively).
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