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Assessment of resistance to colicinogenic synthetic phage antimicrobial system.
Microbiol Spectr
November 2024
Department of Food Science, Cornell University, Ithaca, New York, USA.
Unlabelled: This work presents a multi-hurdle approach that addresses antimicrobial resistance by minimizing the selective pressure of antimicrobials using a novel colicinogenic-phage system. We have created two synthetic T7 phages (T7-E1 and T7-M) by inserting the gene of colicin E1 (Cea) or colicin M (Cma) into the genome of the T7 phage, thereby adding an additional colicin-based hurdle to the T7 lytic cycle. The colicin-phages' efficacy in suppressing the outgrowth of a T7-resistant sub-population within a mixed culture of was demonstrated using a challenge matrix design under planktonic and structured conditions.
View Article and Find Full Text PDFEpigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and neuroimaging data; yet, research in this area is almost entirely comprised of cross-sectional studies in adults.
View Article and Find Full Text PDFResidential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study.
Amyotroph Lateral Scler Frontotemporal Degener
August 2024
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.
Background: Environmental exposures impact amyotrophic lateral sclerosis (ALS) risk and progression, a fatal and progressive neurodegenerative disease. Better characterization of these exposures is needed to decrease disease burden.
Objective: To identify exposures in the residential setting that associate with ALS risk, survival, and onset segment.
Video feedback for young babies and maternal perinatal mental illness: intervention adaptation, feasibility and acceptability.
J Reprod Infant Psychol
March 2024
Department of Psychological Interventions, University of Surrey, Guildford, UK.
Aims/background: We aimed to adapt, pilot and explore experiences of receiving and delivering the video feedback intervention for positive parenting (VIPP) for 2 to 6 month old babies, mothers experiencing moderate to severe perinatal mental health difficulties and perinatal mental health clinicians.
Design/methods: The VIPP intervention was adapted to include developmentally appropriate activities and developmental psychoeducation for 2 to 6 month olds, alongside psychoeducation on emotion regulation, and then piloted in 14 mothers experiencing moderate to severe perinatal mental health difficulties (registration ISRCTN64237883). Observational and self-reported pre-post outcome data on parenting and parent-infant mental health was collected, and post-intervention qualitative interviews were conducted with participating mothers and clinicians.
Cellulose-based carbon nanotubes array with lawn-like 3D architecture for oxygen reduction reaction.
Sci Total Environ
March 2024
Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, CAS Key Laboratory of Renewable Energy Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, China.
The conversion of biomass into high-performance carbon-based materials provides an opportunity to valorize biomass for advanced applications. Achieving this necessitates requires dedicated efforts and innovations in biocarbon synthesis, design, and applications. This study proposes the controllable conversion of biomass-derived cellulose into well-distributed carbon nanotubes (CNTs) by tuning the precipitation of cellulose pyrolysis generated vapors with in-situ formed ferric metal nanoparticles.
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