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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Alabama at Birmingham, Birmingham, AL, USA.
Progranulin is a secreted pro-protein that is necessary for maintaining lysosomal function and exerts anti-inflammatory and neurotrophic effects in the brain. Loss-of-function GRN mutations, most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia (FTD). Other GRN variants are associated with risk for FTD, Alzheimer's disease (AD) and Parkinson's disease.
View Article and Find Full Text PDFThermosensitive liposome-encapsulated gold nanocages for photothermal-modulated drug release and synergistic photothermal therapy.
J Mater Chem B
January 2025
College of Chemistry and Materials Science, Chemical Biology Key Laboratory of Hebei Province, Hebei Research Center of the Basic Discipline of Synthetic Chemistry, Hebei University, Baoding, 071002, P. R. China.
Delivery nanosystems have been widely developed to improve the efficacy of chemotherapy. However, their performance regarding the non-specific leakage of drugs remained unsatisfactory. Herein, gold nanocages (AuNCs) were used as carriers and thermo-sensitive liposome (TSL) as a protective shell to design a camptothecin (CPT)-loaded delivery nanosystem (AuNCs/CPT@TSL) for photothermal-modulated drug release.
View Article and Find Full Text PDFEffects of Saprolegnia parasitica on pathological damage and metabolism of Epithelioma papulosum cyprini cell.
Dev Comp Immunol
December 2024
National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China; National Pathogen Collection Center for Aquatic Animals, Shanghai Ocean University, Shanghai, China; Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, China. Electronic address:
Saprolegniasis is a common fungal disease in aquaculture. It will form white flocculent hyphae on the skin of fish, and the hyphae may grow inward and penetrate into muscle tissue, which will reduce the immunity of the body and eventually lead to death. However, there are still some gaps in the mechanism of the fish body surface against the invasion of Saprolegnia.
View Article and Find Full Text PDFChildren's right to participation in residential care: A staff-based study in Portugal.
Child Abuse Negl
December 2024
Instituto Universitário de Lisboa (ISCTE-IUL), CIS-IUL, Lisboa, Portugal.
Background: Youth in residential care (RC) reveal high-risk trajectories, which require upholding their rights and providing them with opportunities to participate.
Objective: We aimed to identify staff profiles focused on their perceptions of participation and the association with sociodemographic variables.
Participants And Setting: This study included quantitative analysis of qualitative data collected from 87 professionals in the RC (M = 38.
A comprehensive analysis of storage impact on toxicity assessment of ozonated effluents.
J Hazard Mater
December 2024
Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu Province 210094, China. Electronic address:
Neglecting the time intervals between sampling and biological testing can lead to misinterpretation of the hazards associated with advanced oxidation processes when assessed through bioassays. This study investigates changes in the non-specific toxicity of ozonated aromatic compounds and analyzes the factors such as temperature and light exposure influencing these changes during sample storage. The findings reveal a significant decrease in biotoxicity of ozonated effluents, ranging from 41 % to 83 %, within the first four days of storage at 22 °C under natural light exposure.
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