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Endogenous sex steroid hormones and risk of liver cancer among US men: Results from the Liver Cancer Pooling Project.
JHEP Rep
July 2023
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Article Synopsis
- The study examined the relationship between sex steroid hormones and liver cancer incidence, noting that men have higher rates than women, possibly due to androgens increasing risk and estrogens decreasing it.
- Researchers analyzed hormone levels in 275 men who developed liver cancer and 768 who did not, using advanced laboratory techniques to quantify hormone concentrations and assess their association with cancer risk.
- Results showed that elevated levels of androgens and certain estrogen metabolites were linked to an increased risk of liver cancer, while higher levels of DHEA were associated with a decreased risk, suggesting a complex interplay between these hormones in influencing liver cancer susceptibility.
Oxytetracycline-induced inflammatory process without oxidative stress in blue mussels Mytilus trossulus.
Environ Sci Pollut Res Int
July 2023
Department of Marine Ecosystem Functioning, University of Gdańsk, Gdynia, Poland.
Potentially harmful compounds including pharmaceuticals are commonly found in marine waters and sediments. Amongst those, antibiotics and their metabolites are detected worldwide in various abiotic (at concentrations as high as µg/L) and biotic matrices at ng/gram of tissue, posing a risk to non-target species exposed to them such as blue mussels. Amongst those, oxytetracycline (OTC) belongs to the most detected antibiotics in the marine environment.
View Article and Find Full Text PDFTestosterone and type 2 diabetes prevention: translational lessons from the T4DM study.
J Endocrinol
September 2023
ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia.
Testosterone acting via the androgen receptor, and via aromatisation to oestradiol, an activator of the oestrogen receptor, plays key roles in adipose tissue, bone and skeletal muscle biology. This is reflected in epidemiological studies associating obesity and disordered glucose metabolism with lower serum testosterone concentrations and an increased risk of type 2 diabetes (T2D) in men. Testosterone also modulates erythrocytosis and vascular endothelial and smooth muscle cell function, with potential impacts on haematocrit and the cardiovascular system.
View Article and Find Full Text PDFStudies towards the Synthesis of (+)-Dictyoxetane.
Chemistry
December 2022
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
The dolabellane-type diterpene dictyoxetane represents a significant challenge to synthetic organic chemistry. Methodology directed towards the total synthesis of naturally occurring (+)-dictyoxetane is reported. Catalytic asymmetric synthesis of the trans-hydrindane ring system is achieved through chemoselective deoxygenation of the Hajos-Parrish ketone.
View Article and Find Full Text PDFRemoval performance and dissolved organic matter biodegradation characteristics in advection ecological permeable dam reactor.
Environ Technol
June 2023
Key Laboratory of Urban Stormwater System and Water Environment, Ministry of Education, Beijing University of Civil Engineering and Architecture, Beijing, People's Republic of China.
In this present study, an advection ecological permeable dam (AEPD) based on a biofilm reactor was established to investigate pollution control performance and dissolved organic matter (DOM) bio-degradation. The AEPD achieved optimal efficiency-chemical oxygen demand, 6-53 mg/L; total nitrogen concentration, 1.47-6.
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