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Factor associated with and risk of cardiovascular disease in people with uncontrolled hypertension.
Sci Rep
January 2025
Department of Medicine, Division of Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
We aimed to identify and validate factors related to uncontrolled hypertension. Participants treated with at least one antihypertensive drug from the prospective contemporaneous CoLaus|PsyCoLaus study were enrolled. We investigated the association between hypertension status (uncontrolled, defined as systolic blood pressure [SBP] ≥ 140 mm Hg and/or diastolic blood pressure [DBP] ≥ 90 mm Hg, versus controlled hypertension [SBP/DBP < 140/90 mm Hg]) and potential risk factors.
View Article and Find Full Text PDFEffects of salt substitute on urinary electrolytes and blood pressure in a real-world setting-cohort study in Hunan, China.
Front Nutr
December 2024
Department of Epidemiology, Hunan Normal University School of Medicine, Changsha, China.
Article Synopsis
- Salt substitutes are a potential strategy to reduce sodium intake and increase potassium, aiming to lower blood pressure in China; however, their real-world benefits remain unclear.
- A study involving nearly 5,000 participants over a year found that those using salt substitutes had lower sodium excretion and higher potassium levels compared to those restricting salt, although blood pressure control was similar between both groups.
- Results suggested that salt substitutes might improve sodium and potassium levels, though not necessarily blood pressure, particularly with lower potassium content substitutes.
Gene expression & biochemical analysis in alkaptonuria caused by a founder pathogenic variant across different age groups from India.
Indian J Med Res
November 2024
Department of Clinical Genetics, Christian Medical College, Vellore, Tamil Nadu, India.
Background & objectives Alkaptonuria (AKU) is an autosomal recessive disease wherein biallelic pathogenic variants in the homogentisate 1,2- dioxygenase (HGD) gene encoding the enzyme homogentisate 1,2 dioxygenase cause high levels of homogentisic acid (HGA) to circulate within the body leading to its deposition in connective tissues and excretion in urine. A homozygous splice donor variant (c.87+1G>A) has been identified to be the founder variant causing alkaptonuria among Narikuravars, a group of gypsies settled in Tamil Nadu.
View Article and Find Full Text PDFEffect of sex on the levels of total arsenic (As) and As(III) in dog urine: a preliminary study.
Pol J Vet Sci
June 2024
Department of Animal Physiology and Physiotherapy, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Mazowiecka 28, 85-084 Bydgoszcz, Poland.
The aim of the study was to analyze differences in the concentration of total arsenic (As) and As(III) in urine depending on the sex of mixed-breed dogs. Therefore, a research hypothesis was put forward that sex is a variable determining the degree and efficiency of urinary arsenic excretion. Two study groups were established: female (group 1) and male (group 2) mixed-breed dogs of similar body weight (9-13 kg) and aged 8-11 years.
View Article and Find Full Text PDFIodine Deficiency Hypothyroidism Among Children in the United States - 21st Century Resurgence?
AACE Clin Case Rep
August 2024
Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Background/objective: Iodine deficiency hypothyroidism is an important cause of neurocognitive and motor impairment in children globally. In the United States, universal salt iodization, which began in the 1920s, led to a dramatic decline in iodine deficiency hypothyroidism. However, iodine deficiency may be reemerging due to increased consumption of noniodized salts, decreased dairy iodine concentrations, and decreased intake of iodine containing foods due to food allergies, dietary preferences such as vegan diets, or restrictive food intake disorders.
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