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[The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.].
Recenti Prog Med
October 2024
Dipartimento di Cardiologia, Ospedale Santa Maria della Misericordia, Perugia.
The recent guidelines issued by the European Society of Hypertension reaffirmed that the degree of control of hypertension remains suboptimal worldwide. In order to increase the proportion of well-controlled patients, in addition to nonpharmacological measures, it is necessary to improve the implementation of drug therapy in the clinical practice as much as possible. Initial therapy should almost always be based on the combination, free or fixed, between ACE inhibitor drugs, or direct angiotensin II inhibitors ('sartans') and diuretics (thiazide or thiazide-like) or calcium channel blockers at the maximum recommended and well-tolerated dose.
View Article and Find Full Text PDFStructural bases for Na-Cl cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun
August 2024
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Article Synopsis
- The Na-Cl cotransporter (NCC) is crucial for salt reabsorption in the kidneys, influencing electrolyte balance and blood pressure.
- Thiazide and thiazide-like diuretics, which inhibit NCC, have been key treatments for hypertension and edema since the 1950s.
- Research reveals that phosphorylation changes NCC's structure, creating an allosteric network that affects ion translocation, potentially explaining conditions like Familial Hyperkalemic Hypertension.
Effect of antihypertensive agents on sleep apnea and ambulatory blood pressure in patients with hypertension: A randomized controlled trial.
Sleep Med
July 2024
Graduate Program in Cardiology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Division of Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address:
Background: Obstructive sleep apnea (OSA) and hypertension are common conditions that may be linked through sympathetic activation and water retention. We hypothesized that diuretics, which reduce the body water content, may be more effective than amlodipine, a blood pressure (BP)-lowering agent implicated with edema, in controlling OSA in patients with hypertension. We also aimed to compare the effects of these treatments on ambulatory blood pressure monitoring (ABPM).
View Article and Find Full Text PDFChlortalidone (CLT) is a thiazide-type diuretic with high affinity for the erythrocyte carbonic anhydrase. Therapeutically, it is mostly used to treat edema and hypertension due to liver cirrhosis, heart insufficiency, or renal dysfunction. Although diuretics and masking agents are prohibited by the World Anti-Doping Agency (WADA) at all times in sports, substances belonging to this category are constantly detected in athlete samples, according to WADA's annual testing figures.
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