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Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes.
Neurol Neuroimmunol Neuroinflamm
March 2025
Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin.
Background And Objectives: Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.
View Article and Find Full Text PDFExtreme Diffusion Measures Statistical Fluctuations of the Environment.
Phys Rev Lett
December 2024
University of Oregon, Department of Physics and Materials Science Institute, Eugene, Oregon 97403, USA.
We consider many-particle diffusion in one spatial dimension modeled as "random walks in a random environment." A shared short-range space-time random environment determines the jump distributions that drive the motion of the particles. We determine universal power laws for the environment's contribution to the variance of the extreme first passage time and extreme location.
View Article and Find Full Text PDFTemperature-Dependent Magnetic Resonance Relaxation Behaviors in Porous Materials.
Phys Rev Lett
December 2024
University of New Brunswick, UNB MRI Centre, Department of Physics, Fredericton, New Brunswick, E3B 5A3, Canada.
We observe divergent temperature-dependent magnetic resonance relaxation behaviors across various brine-saturated porous materials. The paramagnetic and diamagnetic nature of the samples underlies these divergent behaviors. The temperature-dependent trends of the longitudinal T_{1} and transverse T_{2} relaxation times are systematically explained via distinct relaxation-diffusion regimes of Brownstein-Tarr theory.
View Article and Find Full Text PDFFerromagnetic Semimetal and Charge-Density Wave Phases of Interacting Electrons in a Honeycomb Moiré Potential.
Phys Rev Lett
December 2024
Flatiron Institute, Center for Computational Quantum Physics, New York, New York 10010, USA.
The exploration of quantum phases in moiré systems has drawn intense experimental and theoretical efforts. The realization of honeycomb symmetry has been a recent focus. The combination of strong interaction and honeycomb symmetry can lead to exotic electronic states such as fractional Chern insulator, unconventional superconductor, and quantum spin liquid.
View Article and Find Full Text PDFIntralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
Drug Deliv Transl Res
January 2025
Kinimmune, Inc. St. Louis, 63141, Missouri, USA.
PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.
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