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Towards the discovery of unrevealed flufenamic acid cocrystals via structural resemblance for enhanced topical drug delivery.
Int J Pharm
January 2025
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong. Electronic address:
Cocrystallization has emerged as a promising formulation strategy for modulating transdermal drug absorption by enhancing solubility and permeability. However, challenges related to cocrystal dissociation in the semi-solid state need to be addressed to mitigate regulatory concerns before the widespread implementation of topical cocrystal products in clinical practice. This study aimed to develop oil-based topical formulations incorporating cocrystals with distinct thermodynamic stabilities, followed by investigating the roles of different structurally similar coformers and oily vehicles on their physicochemical properties.
View Article and Find Full Text PDFCanine leishmaniasis caused by Leishmania Tropica in southeastern Iran: a case series study.
Sci Rep
October 2024
Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Dogs are the primary reservoirs of Leishmania infantum (L. infantum), but Leishmania tropica (L. tropica) infection is also possible in dogs and can transmitted to humans.
View Article and Find Full Text PDFA new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice.
Elife
October 2024
College of Medical Laboratory Science, Guilin Medical University, Guangxi, China.
Article Synopsis
- Current cancer treatments struggle with tumor relapse, drug resistance, and inefficient outcomes because some tumor cells can evade the immune system.
- This study introduces a novel immunotherapy approach that uses serum-based antibodies from mice with a type of skin cancer (mCSCC) to target and reduce tumors.
- The experimental process involved isolating mCSCC cells, stimulating healthy mice to produce anti-tumor antibodies, and analyzing serum effects on tumor size and related proteins, showing promising results that warrant further investigation.
Unusual presentation of cytomegalovirus and varicella-zoster virus infection in a patient with good's syndrome: A case report.
Radiol Case Rep
December 2024
Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- A 56-year-old man with Good's syndrome, characterized by a thymoma, developed rare co-infections of cutaneous cytomegalovirus (CMV) and varicella-zoster virus (VZV), showing painful skin lesions.
- Histopathological tests confirmed herpes virus infection, and immunohistochemistry revealed CMV in endothelial cells.
- The patient was successfully treated with intravenous immunoglobulin and ganciclovir, leading to complete resolution of symptoms and improved prognosis upon follow-up.
Bovine papillomavirus in Egypt: clinico-pathological features and molecular evolutionary analysis.
Vet Ital
September 2023
Department of Virology, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef 62511, Egypt.
Bovine papillomatosis is an infectious viral disease of cattle characterized by development of benign cutaneous warts. The present study describes bovine papillomavirus infection in cattle on clinco-pathological and molecular bases and compares the identified strains with the previously characterized papillomavirus isolates in Egypt either of bovine or equine origin. Out of sixty examined cattle, skin lesions were collected from eleven clinically diseased cattle exhibiting typical papillomatosis clinical signs and subjected to histopathological and molecular identification.
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