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Detection of Fast Decliner of Diabetic Kidney Disease Using Chiral Amino Acid Profiling: A Pilot Study.
Chem Biodivers
January 2025
The University of Tokyo: Tokyo Daigaku, 7-3-1, Hongo, 113-8655, Bunkyo-ku, JAPAN.
Biomarkers for the prediction of diabetic kidney disease are still unsatisfactory. Although D-amino acids have been shown to reflect kidney conditions, their efficacy in treating diabetic kidney disease (DKD) has not been demonstrated. This study explored the potential role of D-amino acids as progression markers for DKD, an aspect not addressed previously.
View Article and Find Full Text PDFComparative transcriptomics and metabolomics provide insight into degeneration-related physiological mechanisms of Morchella importuna after long-term preservation.
Microb Biotechnol
January 2025
Sichuan Institute of Edible Fungi, Sichuan Academy of Agricultural Sciences, Chengdu, China.
Ascomycetes fungi are often prone to degeneration. Agricultural production of the prized ascomycete mushroom Morchella importuna (black morel) typically suffers from reduced yield and malformed ascocarps owing to culture degeneration. This study compared M.
View Article and Find Full Text PDFIdentification of a Novel ATP7A Variant in a Chinese Boy With Developmental Delay and Epilepsy.
Int J Dev Neurosci
February 2025
Department of Neurology, Women and Children's Hospital of Ningbo University, Ningbo, China.
Menkes disease (MD) is a rare X-linked recessive syndrome that is caused by mutations in the ATP7A gene, which encodes the P-type ATP enzyme. The ATP7A gene encodes 1500 amino acids and is expressed in a number of organs, including the brain, muscles, kidneys and lungs. ATP7A transports copper between cell membranes using energy generated by ATP hydrolysis.
View Article and Find Full Text PDFMetabolic fuel selection in rainbow trout: Coping with Intralipid infusion.
Am J Physiol Regul Integr Comp Physiol
January 2025
Biology Department, University of Ottawa, Ottawa, Ontario, Canada.
The impact of hyperlipidemia on fuel selection has never been investigated in fish. This study quantifies how Intralipid administration affects: (i) mobilization of lipids (lipolytic rate: glycerol) and carbohydrates (hepatic glucose production: glucose) in rainbow trout, and (ii) key proteins involved in the regulation of fuel metabolism that could explain changes in glycerol and glucose kinetics. Results show that Intralipid triples lipolytic rate (from 2.
View Article and Find Full Text PDFsynergistically supports systemic plant defense response in against .
Front Plant Sci
January 2025
Plant Biochemistry and Physiology, Bielefeld University, Bielefeld, Germany.
The network of antagonistic, neutral, and synergistic interactions between (micro)organisms has moved into the focus of current research, since in agriculture, this knowledge can help to develop efficient biocontrol strategies. Applying the nematophagous fungus as biocontrol agent to manage the root-knot nematode is a highly promising strategy. To gain new insight into the systemic response of plants to a plant-parasitic nematode and a nematophagous fungus, was inoculated with and/or and subjected to transcriptome and metabolome analysis of leaves.
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