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Predicting purulent meningitis in very preterm infants: a novel clinical model.
BMC Pediatr
January 2025
Department of Pediatrics, Qilu Hospital, Shandong University, No.107, West Culture Road, Lixia District, Jinan City, Shandong Province, 250000, China.
Background: Purulent meningitis (PM) is a commonly encountered infectious condition in newborns, which unfortunately can result in infant mortality. Newborns with PM often present nonspecific symptoms. The success of lumbar puncture, an invasive test, relies on the operator's expertise.
View Article and Find Full Text PDFClinical characteristics and mortality risk factors of premature infants with carbapenem-resistant Klebsiella pneumoniae bloodstream infection.
Sci Rep
November 2024
Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, 33 Longhuwaihuan Road, Zhengzhou, 450018, Henan, China.
Article Synopsis
- The study examines the challenges and high mortality rates associated with carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections (BSI) in premature infants.
- It analyzes clinical data from 96 infants with CRKP BSI to identify key risk factors for death, including persistent tachycardia, fever, and apnea at infection onset.
- Identified independent risk factors for mortality include concurrent meningitis and necrotizing enterocolitis, along with a higher vasoactive-inotropic score, while early appropriate antimicrobial treatment was linked to improved survival rates.
Neonatal Mastitis: Clinical Presentation and Approach to Evaluation and Management.
Pediatr Emerg Care
December 2024
From the Professor, Department of Pediatrics, Division of Emergency Medicine, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA.
Mastitis is an uncommon but potentially serious infection in neonates. Characteristic findings include erythema, induration, and tenderness around the breast bud. Fluctuance and purulent drainage may be present with abscess formation.
View Article and Find Full Text PDFCase Report: Primary ciliary dyskinesia due to CCNO mutations: a Chinese pediatric case series and literature review.
Front Pediatr
September 2024
Department of Respiratory Diseases, Shenzhen Children's Hospital Affiliated to Shantou University Medical College, Shenzhen, China.
Article Synopsis
- Primary ciliary dyskinesia (PCD) is a hereditary condition that affects cilia, leading to issues with clearing mucus from the lungs, and this study focuses on PCD linked to mutations in the CCNO gene, involving three Chinese children.
- The cases include an 8-year-old boy diagnosed with respiratory issues akin to diffuse panbronchiolitis, his sister with similar symptoms requiring oxygen, and a 4-year-old girl with a history of pneumonia and recurrent infections, all confirmed to have PCD through genetic testing.
- Key clinical features of CCNO-PCD were identified, such as neonatal respiratory distress, chronic cough, and low nasal nitric oxide levels, indicating that while cilia may appear normal, they
Prevalence and genetic diversity of Parechovirus.
Virus Res
November 2024
Xiangya Hospital, Central South University, Changsha, 410083, China. Electronic address:
Human parechovirus (HPeV) is a common virus that can cause severe infections in newborns. Due to the limited knowledge of the prevalence of HPeV in different cities in China and the unknown association between HPeV infection and clinical characteristics of newborns, this research investigated the epidemiological and clinical characteristics of HPeV infection in hospitalized neonates in Changsha. From August to October 2023, 145 anal swab samples from 96 newborns and 38 pharyngeal swab samples from 33 newborns in the neonatal intensive care unit (NICU) were collected.
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