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Mechanistic analyses reveal that Pueraria montana var. lobata (Willd.) is effective in inhibiting ovarian cancer progression.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Affiliated Lishui Traditional Chinese Medicine Hospital, Zhejiang University of Traditional Chinese Medicine, Lishui, 323000, Zhejiang, China.
Ovarian cancer (OC) is a common malignancies of the female genitalia. P. montana var.
View Article and Find Full Text PDFCoumestrol as a new substance that may diminish lipid precursors of the inflammation in steatotic primary rat hepatocytes.
Biochimie
January 2023
Department of Physiology, Medical University of Bialystok, 15-089, Bialystok, Poland. Electronic address:
Coumestrol is a phytoestrogen found in various plant foods. Increasing evidence ascertained its robust anti-inflammatory, anti-oxidative properties likewise ability to mitigate insulin resistance. Thus, it may be a potential medicine in the treatment of many metabolic disorders, including obesity, type 2 diabetes (T2D) as well as non-alcoholic fatty liver disease (NAFLD).
View Article and Find Full Text PDFNaturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases.
Pharmacol Res
July 2021
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR 999078, China. Electronic address:
Naturally occurring coumestans are known as a collection of plant-derived polycyclic aromatic secondary metabolites which are characterized by the presence of an oxygen heterocyclic four-ring system comprising a coumarin moiety and a benzofuran moiety sharing a C˭C bond. Recently, there is an increasing attention in excavating the medicinal potential of coumestans, particularly coumestrol, wedelolactone, psoralidin and glycyrol, in a variety of diseases. This review is a comprehensive inventory of the chemical structures of coumestans isolated from various plant sources during the period of 1956-2020, together with their reported biological activities.
View Article and Find Full Text PDFIsolate Differences Determine Disease Severity and Phytoestrogen Production in Annual spp.
Plant Dis
October 2021
School of Agriculture and Environment and the Institute of Agriculture, University of Western Australia, Crawley, Western Australia 6009, Australia.
Phoma black stem and leaf spot disease of annual spp., caused by , not only can devastate forage and seed yield but can reduce herbage quality by inducing production of phytoestrogens (particularly coumestrol and 4'-O-methylcoumestrol), which can also reduce the ovulation rates of animals grazing infected forage. We determined the consequent phytoestrogen levels on three different annual species/cultivars ( cultivar Cyprus, var.
View Article and Find Full Text PDFThe Influence of Coumestrol on Sphingolipid Signaling Pathway and Insulin Resistance Development in Primary Rat Hepatocytes.
Biomolecules
February 2021
Department of Physiology, Medical University of Bialystok, 15-274 Bialystok, Poland.
Coumestrol is a phytoestrogen widely known for its anti-diabetic, anti-oxidant, and anti-inflammatory properties. Thus, it gets a lot of attention as a potential agent in the nutritional therapy of diseases such as obesity and type 2 diabetes. In our study, we evaluated whether coumestrol affects insulin resistance development via the sphingolipid signaling pathway in primary rat hepatocytes.
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