Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Adsorption and Corrosion Performance of New Cationic Gemini Surfactants Derivatives of Fatty Amido Ethyl Aminium Chloride with Ester Spacer for Mild Steel in Acidic Solutions.
Materials (Basel)
June 2020
Egyptian Petroleum Research Institute (EPRI), Nasr, 11727 Cairo, Egypt.
Three new cationic gemini surfactants with ester spacer type 2-2'-(ethane-1,2-diyl bis(oxy)) bis(N-(2-alkanamidoethyl)-N,N-dimethyl-2-oxoethan-1-aminium)) dichloride) (CGSES12, CGSES14 and CGSES16), based on ,-dimethyl fatty amido ethylamine, were produced. These gemini quaternary ammonium salts were synthesized using a three-step reaction method, starting from th/e condensation of the fatty acid chloride (RCOCl) of various hydrophobic chain lengths (R, CH, CH, CH) with ,-dimethyl ethylene diamine, followed by the quaternization of the tertiary amino group formed with the spacer of the ester group formed in the second step. The chemical configuration of the surfactants was established by FT-IR, HNMR, CNMR and Mass spectroscopies.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effectiveness of the telomerase inhibitor imetelstat in treating osteosarcoma, a type of bone cancer, using pre-clinical models.
- Results showed that imetelstat alone decreased telomerase activity, caused telomere shortening, and inhibited growth in osteosarcoma cell lines, but didn't fully stop cell growth in bulk cultures.
- The combination of imetelstat and the HSP90 inhibitor alvespimycin led to increased DNA damage and complete growth arrest in cell cultures, and also significantly reduced tumor growth in xenograft models, suggesting that dual targeting is a promising therapeutic strategy.
Polyanionic N-donor ligands as chelating agents in transition metal complexes: synthesis, structural characterization and antiviral properties against HIV.
Dalton Trans
June 2012
Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain.
We describe here the synthesis and characterization of new sulfonated and carboxylated-containing N-donor ligands [Na(4)(edts)]·4H(2)O (2), [Na(2)(dmeddp)]·2H(2)O (3) and [Na(4)(edtp)]·H(2)O (4) (edts = ethylene-diamine- N,N,N',N'-tetraethylenesulfonate ion; dmeddp = dimethyl-ethylene-diamine-N,N,N',N'-tetra-3-propionate ion; edtp = ethylene-diamine-N,N,N',N'-tetra-3-propionate ion) and their corresponding metal (Ni, Co, Cu and Zn) complexes. Mainly, UV-Vis and a computer aided analysis of the EPR spectra provided information on the geometry and structure of the complexes in solution. Some of the metal complexes inhibit HIV replication when treating both pre- and post-infected PBMC cells, and hustle the inhibitory effect compared to the metal salts alone.
View Article and Find Full Text PDF17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types.
Gynecol Oncol
February 2005
Department of Obstetrics and Gynecology, University of Michigan Medical Center, Med. Sci. II, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0618, USA.
Objective: HSP90 is a cellular chaperone that is overexpressed in many cancers. HSP90 assists in proper folding of a variety of clients, many of which are oncoproteins. HSP90 has been shown to be elevated in endometrial, ovarian, and breast cancer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!