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An ACE2-Alamandine Axis Modulates the Cardiac Performance of the Goldfish via the NOS/NO System.
Antioxidants (Basel)
April 2022
Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata, 87036 Rende, Italy.
Alamandine is a peptide of the Renin Angiotensin System (RAS), either generated from Angiotensin A via the Angiotensin Converting Enzyme 2 (ACE2), or directly from Ang-(1-7). In mammals, it elicits cardioprotection via Mas-related G-protein-coupled receptor D (MrgD), and the NOS/NO system. In teleost fish, RAS is known to modulate heart performance.
View Article and Find Full Text PDFLopinavir-Ritonavir in SARS-CoV-2 Infection and Drug-Drug Interactions with Cardioactive Medications.
Cardiovasc Drugs Ther
June 2021
Department of Cardiology, Rashid hospital, Dubai, United Arab Emirates.
Lopinavir-ritonavir combination is being used for the treatment of SARS-CoV-2 infection. A low dose of ritonavir is added to other protease inhibitors to take advantage of potent inhibition of cytochrome (CYP) P450 3A4, thereby significantly increasing the plasma concentration of coadministered lopinavir. Ritonavir also inhibits CYP2D6 and induces CYP2B6, CYP2C19, CYP2C9, and CYP1A2.
View Article and Find Full Text PDFMolecular mechanisms of bufadienolides and their novel strategies for cancer treatment.
Eur J Pharmacol
November 2020
College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, China. Electronic address:
Bufadienolides are cardioactive C24 steroids with an α-pyrone ring at position C17. In the last ten years, accumulating studies have revealed the anticancer activities of bufadienolides and their underlying mechanisms, such as induction of autophagy and apoptosis, cell cycle disruption, inhibition of angiogenesis, epithelial-mesenchymal transition (EMT) and stemness, and multidrug resistance reversal. As Na/K-ATPase inhibitors, bufadienolides have inevitable cardiotoxicity.
View Article and Find Full Text PDFDetermination of higenamine in multi-matrix by gas chromatography-mass spectrometry combined with derivatization technology.
J Food Drug Anal
January 2020
Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, 050021, PR China. Electronic address:
Article Synopsis
- * A new gas chromatography-mass spectrometry (GC-MS) method was developed to accurately measure HG levels in various samples, achieving a high degree of precision and sensitivity.
- * The method showed effective recovery rates and low detection limits for HG in biological fluids and traditional Chinese medicines, indicating its practical application for monitoring potential doping.
A Case Report of Accidental Intoxication following Ingestion of Foxglove Confused with Borage: High Digoxinemia without Major Complications.
Case Rep Cardiol
November 2019
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, Milan, Italy.
Article Synopsis
- Foxglove leaves can be mistaken for borage, a safe food ingredient, but are actually poisonous due to the presence of cardiac glycosides, including digitoxin.
- A 55-year-old woman experienced severe symptoms after eating a pie made with what she thought were borage leaves, leading to her hospitalization with high digoxin levels.
- Further analysis revealed the presence of gitoxin, suggesting it might be more toxic than digoxin, highlighting the need for careful lab interpretation in cases of plant poisoning due to potential misidentification of glycosides.
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