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Hidradenitis suppurativa pathogenesis: Extrinsic factors.
J Am Acad Dermatol
December 2024
Department of Dermatology, University of California, San Francisco, San Francisco, California. Electronic address:
While genetic predisposition and immune dysregulation are recognized as key contributors to the development of hidradenitis suppurativa, accumulating research points to the influence of extrinsic factors in the pathogenesis of this condition. This review explores the roles of mechanical stress, altered skin and gut microbiome, tobacco smoking, diet, and paradoxical drug reactions as drivers of hidradenitis suppurativa onset and progression. A holistic management approach addressing these factors may be encouraged to improve disease outcomes.
View Article and Find Full Text PDFIntrinsic factors in the pathogenesis of hidradenitis suppurativa: Genetics, hormones, and the microbiome.
J Am Acad Dermatol
December 2024
Skin Hospital, Darlinghurst, Sydney, Australia; University of New South Wales, Sydney, Australia; Laboratory of Translational Cutaneous Medicine, Ingham Institute, Sydney, Australia; Department of Dermatology, Liverpool Hospital, Sydney, Australia. Electronic address:
The pathogenesis of hidradenitis suppurativa is complex and multifaceted. Our understanding of disease mechanisms is in constant flux with new genetic, inflammatory, and microbiological insights upending previous paradigms and enlightening us as to the complex connections between different drivers of disease. This updated review integrates novel genetic insights from genome wide association studies, along with novel basic science data from single cell transcriptomic studies and recent interventional translational work to inform our evolving understanding of the disease.
View Article and Find Full Text PDFFollicular Skin Disorders, Inflammatory Bowel Disease, and the Microbiome: A Systematic Review.
Int J Mol Sci
September 2024
School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Article Synopsis
- Follicular skin disorders, such as hidradenitis suppurativa (HS), often occur alongside systemic autoinflammatory diseases like inflammatory bowel disease (IBD) and its variants (Crohn's and ulcerative colitis).
- This systematic review examined the link between follicular skin disorders, IBD, and the human microbiome, noting that gut dysbiosis may relate to both HS severity and dietary influences.
- The findings suggest dietary changes could help manage these conditions, while further research is necessary to clarify the microbiome's role in the interaction between HS and IBD.
Insights into Gut Microbiome Composition in Hidradenitis Suppurativa: A Comprehensive Examination of Dietary Habits and Environmental Influences.
Nutrients
June 2024
Department of Dermatology, Venereology, and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Article Synopsis
- The study investigates how dietary habits and environmental factors affect the gut microbiome in people with hidradenitis suppurativa (HS), a chronic skin condition, by analyzing data from 80 participants, split between HS patients and healthy controls.
- Although no significant differences were found in overall microbiome diversity between the two groups, HS patients were found to consume more sugar and milk.
- The research highlights a correlation between coffee consumption and specific bacteria, suggesting that while microbiome diversity wasn’t affected, dietary habits could offer new opportunities for managing HS through lifestyle changes.
The Association Between Hidradenitis Suppurativa and Diet: An Update.
Acta Dermatovenerol Croat
December 2023
Prof. Zrinka Bukvić Mokos, MD, PhD, School of Medicine, University of Zagreb, Department of Dermatology and Venereology, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia;
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful inflammatory lesions, predominantly affecting areas of the skin rich in apocrine glands, such as inguinal, axillary, submammary, and anogenital regions, with an estimated global prevalence between 1%-4%. The treatment of HS is challenging with various treatment modalities employed to control the disease. Since the condition is chronic and life-impairing, many patients have looked for ways to complement their conventional treatment procedures with non-medical interventions, among which dietary interventions have been of particular interest.
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