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Endonasal Endoscopy for a Suprasellar Craniopharyngioma in a 16-Month Child: A Technical Report, 2-Dimensional Operative Video.
Oper Neurosurg (Hagerstown)
January 2025
Department of ENT, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Treatment of patients with tumor/treatment-related hypothalamic obesity in the first two years following surgical treatment or radiotherapy.
Sci Rep
January 2025
Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Carl Von Ossietzky Universität, Klinikum Oldenburg AöR, Rahel-Straus-Straße 10, 26133, Oldenburg, Germany.
Survivors of sellar/suprasellar tumors involving hypothalamic structures face a risk of impaired quality of life, including tumor- and/or treatment-related hypothalamic obesity (TTR-HO) defined as abnormal weight gain resulting in severe persistent obesity due to physical, tumor- and/or treatment related damage of the hypothalamus. We analyze German claims data to better understand treatment pathways for patients living TTR-HO during the two years following the index surgical treatment. A database algorithm identified patients with TTR-HO in a representative German payer claims database between 2010 and 2021 (n = 5.
View Article and Find Full Text PDFCohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study).
Ann Pediatr Endocrinol Metab
December 2024
Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Rare endocrine diseases are complex conditions that require lifelong specialized care due to their chronic nature and associated long-term complications. In Korea, a lack of nationwide data on clinical practice and outcomes has limited progress in patient care. Therefore, the Multicenter Networks for Ideal Outcomes of Pediatric Rare Endocrine and Metabolic Disease (OUTSPREAD) study was initiated.
View Article and Find Full Text PDFRadiation therapy for childhood-onset craniopharyngioma: systematic review and meta-analysis.
J Neurooncol
January 2025
Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China.
Background: Craniopharyngioma (CP), a benign tumor originating from remnants of Rathke's pouch in the sellar region, accounts for approximately 30% of all cases of craniopharyngioma. Radiation therapy has been used to treat CP patients for decades; however, there is still a lack of systematic reviews on the long-term tumor control outcomes in pediatric CP patients treated with external radiation therapy.
Methods: We conducted a comprehensive search of multiple databases for studies on the tumor progression rates of childhood-onset CP(COCP) patients who received external radiotherapy.
A single-center experience of central nervous system tumors in children under three years old.
Front Pediatr
December 2024
Department of Neurosurgery, Tsinghua University Yuquan Hospital (Tsinghua University Hospital of Integrated Traditional Chinese and Western Medicine), Beijing, China.
Article Synopsis
- This study examines young children (≤3 years) with central nervous system tumors, analyzing their characteristics and overall survival (OS) over a period from 2016 to 2023.
- The research involved 171 patients with follow-up data from 162, identifying common tumor types, treatment strategies like gross total resection (GTR), and how factors such as tumor grade and the degree of resection influence survival outcomes.
- Findings highlight that GTR is crucial for treatment, except in specific tumor types, while the interaction between resection extent and tumor grade, along with the Ki-67 labeling index, are the key determinants of OS, suggesting the benefit of targeted chemotherapy.
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