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Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability.
Transl Psychiatry
October 2024
MIND Institute, University of California Davis School of Medicine, Sacramento, CA, 95817, USA.
Disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability (SRID). Without functional SynGAP1 protein, individuals are developmentally delayed and have prominent features of intellectual disability (ID), motor impairments, and epilepsy. Over the past two decades, there have been numerous discoveries indicating the critical role of Syngap1.
View Article and Find Full Text PDFSleep in the East African root rat, Tachyoryctes splendens.
J Exp Zool A Ecol Integr Physiol
December 2024
School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
The present study reports the results of an electrophysiological analysis of sleep in the East African root rat, Tachyoryctes splendens, belonging to the rodent subfamily Spalacinae. Telemetric electroencephalographic (EEG) and electromyographic recordings, with associated video recording, on three root rats over a continuous 72 h period (12 h light/12 h dark cycle) were analyzed. The analysis revealed that the East African root rat has a total sleep time (TST) of 8.
View Article and Find Full Text PDFHyperexcitability and translational phenotypes in a preclinical mouse model of Related Intellectual Disability.
Res Sq
March 2024
MIND Institute, University of California Davis School of Medicine, Sacramento, CA 95817.
Disruption of directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability (SRID). Without functional SynGAP1 protein, individuals are developmentally delayed and have prominent features of intellectual disability, motor impairments, and epilepsy. Over the past two decades, there have been numerous discoveries indicting the critical role of Syngap1.
View Article and Find Full Text PDFis a critical gene for neuronal development, synaptic structure, and function. Although rare, the disruption of directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1 -related intellectual disability. Without functional SynGAP1 protein, patients present with intellectual disability, motor impairments, and epilepsy.
View Article and Find Full Text PDFSub-Scalp Implantable Telemetric EEG (SITE) for the Management of Neurological and Behavioral Disorders beyond Epilepsy.
Brain Sci
August 2023
Zucker School of Medicine at Hofstra-Northwell, Neurology Northwell Health, 611 Northern Blvd, Great Neck, New York, NY 11021, USA.
Sub-scalp Implantable Telemetric EEG (SITE) devices are under development for the treatment of epilepsy. However, beyond epilepsy, continuous EEG analysis could revolutionize the management of patients suffering from all types of brain disorders. This article reviews decades of foundational EEG research, collected from short-term routine EEG studies of common neurological and behavioral disorders, that may guide future SITE management and research.
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