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Soluplus-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications.
Int J Mol Sci
February 2025
Department of Chemistry, School of Science, University of Navarra, 31080 Pamplona, Spain.
Poor water solubility remains a significant challenge in the pharmaceutical industry that limits the therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus (SLP), an amphiphilic graft copolymer made of polyethylene glycol, polyvinyl caprolactam, and polyvinyl acetate, has been gaining interest in recent years as it addresses these limitations by acting as a versatile carrier. Its ability to form stable amorphous dispersions and enhance drug solubility, as well as its physicochemical properties, support its role as a key excipient in advanced drug delivery systems.
View Article and Find Full Text PDF3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti- Studies.
Pharmaceutics
January 2025
Institute of Chemistry Rosario, National Council for Scientific and Technical Research (IQUIR-CONICET), Rosario 2000, Argentina.
: Chagas disease is a neglected tropical disease caused by infection with the parasite . Benznidazole and nifurtimox are the only approved drugs for treating this condition, but their low aqueous solubility may lead to erratic bioavailability. This work aimed for the first time to formulate tablets of nifurtimox by hot melt extrusion coupled with 3D printing as a strategy to increase drug dissolution and the production of tablets with dosage on demand.
View Article and Find Full Text PDFDrug Property Optimization: Design, Synthesis, and Characterization of Novel Pharmaceutical Salts and Cocrystal-Salt of Lumefantrine.
Mol Pharm
February 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of spp. and prevents malaria pathogens from producing nucleic acid and protein, thereby eliminating the parasites.
View Article and Find Full Text PDFEtiological and histomorphological studies on early chick mortality in broiler chicken in Kashmir, India.
Open Vet J
November 2024
Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-K, Srinagar, India.
Background: Early chick mortality (ECM) is one of the most important problems of the poultry industry that causes severe economic losses to the farmers. The chick mortality varies in different geographical locations and its etiological factor also varies.
Aim: The aim of the present work was to isolate and identify various etiological agents responsible for causing ECM in broilers, and study the overall occurrence and pathology of various disease conditions responsible for causing ECM in broilers.
Molecular Chain Rearrangement of Natural Cellulose-Based Artificial Interphase for Ultra-Stable Zn Metal Anodes.
Angew Chem Int Ed Engl
February 2025
State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin, 300457, China.
The unstable electrolyte-anode interface, plagued by parasitic side reactions and uncontrollable dendrite growth, severely hampers the practical implementation of aqueous zinc-ion batteries. To address these challenges, we developed a regenerated cellulose-based artificial interphase with synergistically optimized structure and surface chemistry on the Zn anode (RC@Zn), using a facile molecular chain rearrangement strategy. This RC interphase features a drastically increased amorphous region and more exposed active hydroxyl groups, facilitating rapid Zn diffusion and homogeneous Zn interface distribution, thereby enabling dendrite-free Zn deposition.
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