AI Article Synopsis
- Trehalose is a disaccharide found in organisms that can survive extreme dehydration and helps maintain the stability of biomembranes, though its exact mechanism is still unknown.
- Researchers investigated trehalose's hydration properties compared to other oligosaccharides and found that trehalose has the highest ability to hydrate water molecules in its solutions.
- This superior hydration ability may explain why trehalose offers the best stabilizing effect on lipid bilayer structures, enhancing the stability of the water environment around the lipids.
Article Abstract
The disaccharide trehalose extensively exists in anhydrobiotic organism and is considered to play an important role in preserving the integrity of biomembrane. However, the preserving mechanism remains unclear. In this report, we examine the hydration abilities of trehalose and several oligosaccharides composed of alpha-D-glucopyranosyl residues. The unfrozen water fraction per molecule was determined from differential scanning calorimetry measurements of their aqueous solutions. Further, the NMR relaxation time of the natural abundance 17O of water is measured for several saccharide solutions. These results indicate that trehalose has the highest hydration ability among the saccharides studied. In other words, trehalose can effectively lower the mobility of water molecules hydrogen-bonded with saccharides. It is thus reasonable that, among the disaccharides studied, trehalose exhibits the maximum stabilizing effect on the bilayer structure of lipid whose acyl chains are bonded with each other by the apolar interaction, because the apolar interaction is strengthened with the stabilization of the surrounding water structure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0011-2240(92)90064-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydration of 3-Methyl-1,2,3-butanetricarboxylic Acid Evidenced by Matrix-Isolation Infrared Spectroscopy.
J Phys Chem A
January 2025
Institut des Sciences Moléculaires, UMR CNRS 5255, Univ. Bordeaux, Talence cedex F-33405, France.
The hydration mechanism of 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA), a relevant marker of secondary organic aerosol formation from the atmospheric oxidation of α-pinene, has been investigated using the matrix-isolation infrared spectroscopy technique. The experimental results were supported by theoretical calculations. Monomers of MBTCA and heterocomplexes MBTCA-(HO) were identified.
View Article and Find Full Text PDFHigh-Efficiency Electrochemiluminescence Biosensor with Antifouling and Antibacterial Functions for Sensitive and Accurate Analysis of Chloramphenicol in Seawater.
Anal Chem
January 2025
Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
In marine environmental monitoring, due to the presence of a large number of interfering proteins and bacteria in seawater, it is of great significance to construct an efficient sensing interface with antifouling and antibacterial functions to avoid the aforementioned interferences. On this basis, the zwitterionic hydrogel based on sulfobetaine methacrylate (SBMA) and bovine serum albumin (BSA) was developed as an antifouling and antibacterial coating. The combination of hydration of zwitterions and hydrophilicity of hydrogels endows BSA@PSBMA with good antiadsorption ability, which effectively hinders the adhesion of proteins and bacteria, thereby improving the detection sensitivity of the biosensor.
View Article and Find Full Text PDFChallenges Faced by Patients Undergoing Fecal Ostomy Surgery: A Qualitative Study of Colorectal Cancer Patient Perspectives.
J Gastrointest Surg
January 2025
Ariadne Labs, Brigham and Women's Hospital, Harvard. T.H. School of Public Health, Boston, MA, 02115; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114; Mongan Institute Center for Aging and Serious Illness, Massachusetts General Hospital, Boston, MA, 02114. Electronic address:
Background: Ostomy education and support is instrumental in surgical recovery and adaptation. We aimed to evaluate 1) challenges faced by fecal ostomy patients with colorectal cancer and 2) resources necessary for recovery.
Methods: We recruited patients 21-90 days after scheduled fecal ostomy surgery for locally advanced or metastatic colorectal cancer from a single, tertiary academic center.
Hydrated cable bacteria exhibit protonic conductivity over long distances.
Proc Natl Acad Sci U S A
January 2025
Electronics Sciences and Technology Division, United States Naval Research Laboratory, Washington, DC 20375.
This study presents the direct measurement of proton transport along filamentous , or cable bacteria. Cable bacteria are filamentous multicellular microorganisms that have garnered much interest due to their ability to serve as electrical conduits, transferring electrons over several millimeters. Our results indicate that cable bacteria can also function as protonic conduits because they contain proton wires that transport protons at distances >100 µm.
View Article and Find Full Text PDFPotential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid.
Int J Nanomedicine
January 2025
Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion, 26504, Greece.
Introduction: FTY720 bioactive lipid has proliferative, osteoinductive, chemo attractive, and angiogenic properties, being thus a potential exogenous administered agent for promotion of bone regeneration. Herein we developed FTY720-loaded liposomes as a potential delivery system that could retain and prolong the bioactivity of the bioactive lipid and at the same time reduce its cytotoxicity (at high doses).
Methods: FTY720 liposomes were prepared by thin-lipid hydration and microfluidic flow focusing, and evaluated for their ability to induce proliferation, osteoinduction, and chemoattraction in three cell types: MC3T3-E1 pre-osteoblast cells, L929 fibroblast cells, and ATDC5 chondrogenic cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!