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Loss of hepatocyte growth factor activator inhibitor type 1 (HAI-1) upregulates MMP-9 expression and induces degradation of the epidermal basement membrane.
Hum Cell
December 2024
Section of Oncopathology and Morphological Pathology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miazaki, 889-1692, Japan.
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), which is encoded by the SPINT1 gene, is a membrane-associated serine proteinase inhibitor abundantly expressed in epithelial tissues. We had previously demonstrated that HAI-1 is critical for placental development, epidermal keratinization, and maintenance of keratinocyte morphology by regulating cognate proteases, matriptase and prostasin. After performing ultrastructural analysis of Spint1-deleted skin tissues, our results showed that Spint1-deleted epidermis exhibited partially disrupted epidermal basement-membrane structures.
View Article and Find Full Text PDFPlacental extracellular vesicles from women with severe preeclampsia alter calcium homeostasis in cardiomyocytes: an ex vivo study.
Am J Physiol Cell Physiol
January 2025
Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Women with severe preeclampsia (sPE) exhibit a heightened risk of postpartum cardiovascular disease compared with those with normotensive pregnancies (NTP). Although placental extracellular vesicles (EVs) play a crucial role in feto-maternal communication, their impact on cardiomyocytes, particularly in the context of sPE, remains unclear. This study investigated the effect of sPE-associated placental EVs (sPE-Plex EVs) on cardiomyocyte calcium dynamics.
View Article and Find Full Text PDFTaprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.
J Neuroinflammation
November 2024
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, PR China.
Background And Purpose: Neurodevelopmental disorders (NDDs) are characterized by abnormalities in brain development and neurobehaviors, including autism. The maternal-fetal interface (MFI) is a highly specialized tissue through which maternal factors affect fetal brain development. However, limited research exists on restoring and maintaining MFI homeostasis and its potential impact on NDDs.
View Article and Find Full Text PDFDaphnetin Modulates Immune Balance and Enhances Pregnancy Viability in a Mouse Model of Unexplained Recurrent Abortion.
Discov Med
November 2024
Department of Reproductive Center, Jiangxi Maternity and Child Healthcare Hospital, 330006 Nanchang, Jiangxi, China.
Article Synopsis
- Daphnetin shows potential in correcting the imbalance between Th17 cells and Treg cells in a mouse model of unexplained recurrent spontaneous abortion (URSA), as indicated by decreased ratios of these cells.
- The research involved various dosing groups of mice, with numerous methods used to analyze changes in cell ratios, cytokine expression, and tissue structure.
- Results show that daphnetin not only reduces harmful Th17 cell-related cytokines but also enhances beneficial Treg cell-related cytokines, leading to lower embryo absorption rates and improved tissue structure.
Copaifera spp. oleoresins control Trypanosoma cruzi infection in human trophoblast cells (BeWo) and placental explants.
Biomed Pharmacother
October 2024
Laboratory of Immunophysiology of Reproduction, Institute of Biomedical Science, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address:
Congenital Chagas disease (CCD) is a worldwide neglected problem with significant treatment limitations. This study aimed to evaluate the potential of Copaifera spp. oleoresins (ORs) against Trypanosoma cruzi infection in trophoblast cells (BeWo lineage) and human chorionic villous explants (HCVE).
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