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http://dx.doi.org/10.1073/pnas.52.6.1489 | DOI Listing |
Cancer Pathog Ther
January 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL 60607, USA.
Background: High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of all ovarian cancer-related deaths. Multiple studies have suggested that the fallopian tube epithelium (FTE) serves as the cell of origin of HGSOC. Phosphatase and tensin homolog () is a tumor suppressor and its loss is sufficient to induce numerous tumorigenic changes in FTE, including increased migration, formation of multicellular tumor spheroids (MTSs), and ovarian colonization.
View Article and Find Full Text PDFJ Ginseng Res
January 2025
College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
DNA damage is a driver of cancer formation, leading to the impairment of repair mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic approaches. The concept of "synthetic lethality" in cancer clinics has emerged, particularly with the use of PARP inhibitors and the identification of DNA damage response (DDR) mutation biomarkers, emphasizing the significance of targeting DDR in cancer therapy. Novel approaches aimed at genome maintenance machinery are under development to further enhance the efficacy of cancer treatments.
View Article and Find Full Text PDFLife Metab
August 2023
Centre for Neuroendocrinology, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Butein, a rare chalcone found in the toxic plant , has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta (IKKβ)/nuclear factor kappa B (NF-κB) pathway in the brain. Here, we investigated whether the nonpoisonous plant could be a source of butein as a potential treatment for type 2 diabetes (T2D). In mice fed a high-fat diet (HFD) to induce glucose intolerance, an oral petal extract improved glucose tolerance at doses of 3.
View Article and Find Full Text PDFNanoscale Horiz
January 2025
Institute of Materials Science of Barcelona (ICMAB-CSIC), Campus de la UAB, 08193, Bellaterra, Spain.
High-refractive-index (HRI) dielectrics are gaining increasing attention as building blocks for compact lasers. Their ability to simultaneously support both electric and magnetic modes provides greater versatility as compared to plasmonic platforms. Moreover, their reduced absorption loss minimizes heat generation, further enhancing their performance.
View Article and Find Full Text PDFMacromol Rapid Commun
January 2025
Chimie ParisTech, CNRS, Institut de Recherche de Chimie Paris, PSL University, Paris, 75005, France.
The development of catalysts that are both robust and highly active at room temperature can often be seen as a major challenge in anionic polymerization. However, these properties are desirable for polymer synthesis because they allow for easy and sustainable production of interesting materials. Here, iron and magnesium complexes are used to form in situ generated metalate complexes that are shown to be highly active in the room temperature copolymerization of methyl methacrylate and lactide.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!