Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2165860 | PMC |
| http://dx.doi.org/10.1136/bmj.1.5433.520-a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evidence of altered monoamine oxidase B, an astroglia marker, in early psychosis and high-risk state.
Mol Psychiatry
November 2024
Clinical and Translational Sciences Lab, Douglas Research Centre, Montreal, QC, Canada.
Article Synopsis
- A novel radiotracer, [C]SL25.1188, targets monoamine oxidase-B (MAO-B) enzyme primarily in astrocytes, linking its levels to altered astrocyte functions observed in schizophrenia.
- A PET scan study involving 38 participants (14 with first-episode psychosis, 7 at clinical high risk, and 17 healthy volunteers) measured MAO-B concentration and found significantly lower levels in the high-risk group compared to healthy individuals.
- The study also revealed that cannabis use impacted MAO-B levels, with a greater reduction in MAO-B concentration found in individuals using cannabis, emphasizing the potential role of astrocyte dysfunction in early psychosis and high-risk states.
Hypertensive Emergency Secondary to Combining Psilocybin Mushrooms, Extended Release Dextroamphetamine-Amphetamine, and Tranylcypromine.
J Psychoactive Drugs
June 2024
Department of Psychiatry, McLean Hospital, Belmont, MA, USA.
Data on medication interactions with psychedelics are limited. Here we present what may be the first published report of a hypertensive emergency following the combination of psilocybin mushrooms with a monoamine oxidase inhibitor (MAOI). A 42-year-old man with treatment-resistant major depressive disorder took 1 g of mushrooms, while prescribed tranylcypromine, extended-release dextroamphetamine-amphetamine, and other medications.
View Article and Find Full Text PDFThe role of astrocytic γ-aminobutyric acid in the action of inhalational anesthetics.
Eur J Pharmacol
May 2024
Department of Anesthesiology and Pain Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea; College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:
Background: Inhalational anesthetics target the inhibitory extrasynaptic γ-aminobutyric acid type A (GABA) receptors. Both neuronal and glial GABA mediate tonic inhibition of the extrasynaptic GABA receptors. However, the role of glial GABA during inhalational anesthesia remains unclear.
View Article and Find Full Text PDFExpert Opinion on Anesthetic Considerations For Patients Receiving a Classic Monoamine Oxidase Inhibitor.
Anesth Analg
October 2024
PsychoTropical Research, Bucasia, Queensland, Australia.
NLRP3-GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice.
J Neuroinflammation
July 2023
Department of Anesthesiology, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou, China.
Background: Perioperative neurocognitive disorders (PND), such as delirium and cognitive impairment, are commonly encountered complications in aged patients. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is aberrantly synthesized from reactive astrocytes following inflammatory stimulation and is implicated in the pathophysiology of neurodegenerative diseases. Additionally, the activation of NOD-like receptor protein 3 (NLRP3) inflammasome is involved in PND.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!