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Theta and beta power in the subthalamic nucleus responds to conflict across subregions and hemispheres.
Brain Commun
January 2025
Department of Neurological Surgery, University of Louisville, Louisville, KY 40202, USA.
The subthalamic nucleus is thought to play a crucial role in controlling impulsive actions. Networked among the basal ganglia and receiving input from several cortical areas, the subthalamic nucleus is well positioned to influence action selection when faced with competing and conflicting action outcomes. The purpose of this study was to test the dissociable roles of the dorsal and ventral aspects of the subthalamic nucleus during action conflict in patients with Parkinson's disease undergoing intraoperative neurophysiological recording and to explore a potential mechanism for this inhibitory control.
View Article and Find Full Text PDFAdult phenotypes of genetic developmental and epileptic encephalopathies.
Brain Commun
January 2025
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Developmental and epileptic encephalopathies constitute a group of severe epilepsies, with seizure onset typically occurring in infancy or childhood, and diverse clinical manifestations, including neurodevelopmental deficits and multimorbidities. Many have genetic aetiologies, identified in up to 50% of individuals. Whilst classically considered paediatric disorders, most are compatible with survival into adulthood, but their adult phenotypes remain inadequately understood.
View Article and Find Full Text PDFPsychophysical assessment of color vision with the Cambridge Color Vision Test in unilateral functional amblyopia.
Arq Bras Oftalmol
January 2025
Research Nucleus in Neuroscience and Behavior and Applied Neuroscience, Universidade de São Paulo, São Paulo, SP, Brazil.
Purpose: Amblyopia is a cortical neurological disorder caused by abnormal visual experiences during the critical period for visual development. Recent works have shown that, in addition to the well-known visual alterations, such as changes in visual acuity, several perceptual aspects of vision are affected. This study aims to analyze and compare the effects of different types of amblyopia on visual color processing and determine whether these effects are correlated with visual acuity.
View Article and Find Full Text PDFPET Reporter Probes for Brain Imaging of Transduced Gene and Cell Expression: Status and Challenges.
J Med Chem
January 2025
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892 United States.
Article Synopsis
- Gene therapy and cell transduction are emerging as promising treatments for neurological and psychiatric disorders, with PET imaging playing a key role in assessing treatment effectiveness.
- The success of PET imaging relies on the creation of specific radiotracers that can identify exogenous transgenes or modified cells in the brain, potentially eliminating the need for invasive procedures.
- This article discusses the current state and challenges in developing PET probes for monitoring gene therapy and cellular interventions, highlighting the importance of radiochemical development and practical applications in a clinical setting.
The correlations between demographic factors, self-efficacy, and quality of life among Indonesian patients with ischemic stroke: A cross-sectional study.
Belitung Nurs J
January 2025
Department of Nursing, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Background: Ischemic stroke is the primary cause of neurological disability and can lead to psychological issues that affect self-efficacy. Changes in self-efficacy, in turn, influence the overall quality of life. Although many studies have examined factors that affect self-efficacy, quality of life, or both, few have specifically explored the role of demographic factors in shaping the quality of life in patients with ischemic stroke.
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