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Safety and efficacy of unpreserved timolol 0.1% gel in patients controlled by preserved latanoprost with signs of ocular intolerance.
J Fr Ophtalmol
April 2013
Laboratoires Théa, 12, rue Louis-Blériot, 63000 Clermont-Ferrand, France.
Purpose: To assess the safety and efficacy of unpreserved timolol 0.1% gel in ocular hypertensive (OHT) or glaucomatous patients controlled by preserved latanoprost 0.005% but with signs of ocular intolerance.
View Article and Find Full Text PDFNeuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.
Proc Natl Acad Sci U S A
January 2013
Biozentrum, University of Basel, 4056 Basel, Switzerland.
Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites.
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