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The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway.
Eur J Med Chem
January 2025
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:
Gastric cancer remains one of the global health threats for human beings. However, the therapeutic efficacy of the widely-used chemotherapy is usually limited due to the lack of specificity and the related toxicity. Only limited therapeutic agents were demonstrated to show selective and potent inhibitory activity to gastric cancer cells.
View Article and Find Full Text PDFOsteoporosis: Causes, Mechanisms, Treatment and Prevention: Role of Dietary Compounds.
Pharmaceuticals (Basel)
December 2024
Department of Physiology, Faculty of Medicine, University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, 46010 Valencia, Spain.
Osteoporosis is a chronic disease that is characterized by a loss of bone density, which mainly affects the microstructure of the bones due to a decrease in bone mass, thereby making them more fragile and susceptible to fractures. Osteoporosis is currently considered one of the pandemics of the 21st century, affecting around 200 million people. Its most serious consequence is an increased risk of bone fractures, thus making osteoporosis a major cause of disability and even premature death in the elderly.
View Article and Find Full Text PDFThe Phytochemical Profile of the Petroleum Ether Extract of Leaves and Its Anticancer Effect on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None (NNK)-Induced Lung Cancer in Rats.
Int J Mol Sci
December 2024
Medicinal and Aromatic Plants Research Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
Lung cancer is a prevalent and very aggressive sickness that will likely claim 1.8 million lives by 2022, with an estimated 2.2 million additional cases expected worldwide.
View Article and Find Full Text PDFConvergent evolution: What do cats, catnip, aphids, and mosquitoes have in common?
J Biosci
December 2024
Editor-in-Chief, Journal of Biosciences,Centre for Ecological Sciences, Indian Institute of Science,Bengaluru 560012,India.
The well-known English naturalist John Ray wrote more than 200 years ago about the curious reaction of cats to a plant in the mint or Lamiaceae family, the catnip plant . Ray even wrote a short verse about the relationship between cats and catnip: 'If you set it the cats will eat it; If you sow it the cats can't know it' (Considine 2016). When leaves of this plant are bruised and release their volatiles, cats react by attempting to rub and roll over on the leaves, seeming to be in a state of ecstasy.
View Article and Find Full Text PDFSkin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa.
Immunity
December 2024
The Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA; Department of Cell Biology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address:
Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease characterized by keratinized epithelial tunnels that grow deeply into the dermis. Here, we examined the immune microenvironment within human HS lesions. Multi-omics profiling and multiplexed imaging identified tertiary lymphoid structures (TLSs) near HS tunnels.
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