Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach.
Biogerontology
January 2025
Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
The growing prevalence of age-related cardiovascular diseases (CVDs) poses significant health challenges, necessitating the formulation of novel treatment approaches. GATA4, a vital transcription factor identified for modulating cardiovascular biology and cellular senescence, is recognized for its critical involvement in CVD pathogenesis. This review collected relevant studies from PubMed, Google Scholar, and Science Direct using search terms like 'GATA4,' 'cellular senescence,' 'coronary artery diseases,' 'hypertension,' 'heart failure,' 'arrhythmias,' 'congenital heart diseases,' 'cardiomyopathy,' and 'cardiovascular disease.
View Article and Find Full Text PDFGround validation of manipulator adaptive variable admittance control method for detumbling a space noncooperative satellite.
Sci Rep
January 2025
Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China.
To achieve rapid and stable detumbling of a space noncooperative satellite, an adaptive variable admittance control method for the manipulator is proposed and verified through simulation study and the ground experiment. The control block diagram of the proposed method is presented, and the adaptive variable admittance compliant detumbling control model is established. The proposed controller includes the fixed admittance controller in manipulator task space, the adaptive pose compensator for the grasping point on docking ring, and the damping adaptive regulator based on manipulator joint angular velocity, and the stability is proven by the Lyapunov method.
View Article and Find Full Text PDFFragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding-based methodology.
J Cheminform
January 2025
Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford, UK.
Current strategies centred on either merging or linking initial hits from fragment-based drug design (FBDD) crystallographic screens generally do not fully leaverage 3D structural information. We show that an algorithmic approach (Fragmenstein) that 'stitches' the ligand atoms from this structural information together can provide more accurate and reliable predictions for protein-ligand complex conformation than general methods such as pharmacophore-constrained docking. This approach works under the assumption of conserved binding: when a larger molecule is designed containing the initial fragment hit, the common substructure between the two will adopt the same binding mode.
View Article and Find Full Text PDFErring on the side of caution: Two failures to replicate the derring effect.
J Exp Psychol Gen
January 2025
Centre for Perception and Cognition, School of Psychology, University of Southampton.
It has been claimed that deliberately making errors while studying, even when the correct answers are provided, can enhance memory for the correct answers, a phenomenon termed the derring effect. Such deliberate erring has been shown to outperform other learning techniques, including copying and underlining, elaborative studying with concept mapping, and synonym generation. To date, however, the derring effect has only been demonstrated by a single group of researchers and in a single population of participants.
View Article and Find Full Text PDFA Systematic Review on the Evolution of Power Analysis Practices in Psychological Research.
Psychol Belg
January 2025
Department of Data-Analysis, Ghent University, Belgium.
Performing hypothesis tests with adequate statistical power is indispensable for psychological research. In response to several large-scale replication projects following the replication crisis, concerns about the root causes of this crisis - such as questionable research practices (QRPs) - have grown. While initial efforts primarily addressed the inflation of the type I error rate of research due to QRPs, recent attention has shifted to the adverse consequences of low statistical power.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!