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Adenoviral Therapy for Cervical Cancer: From Targeted Modification to Immunotherapy.
Anticancer Agents Med Chem
January 2025
Department of Gynecology, Lanzhou University Second Hospital Lanzhou University, Lanzhou, 730030, China.
Cervical cancer is a significant global health threat, ranking as the fourth most common malignancy among women and resulting in over 300,000 deaths annually. Although screening and vaccination initiatives have led to a decline in incidence rates, treatment options for advanced or recurrent cervical cancer remain inadequate, often proving ineffective and costly. In this context, adenoviral therapy has emerged as a promising strategy to enhance therapeutic outcomes.
View Article and Find Full Text PDFAcute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population's vulnerability, we conducted the hospital-based surveillance of respiratory viruses in Eastern Uttar Pradesh.
View Article and Find Full Text PDFPrevalence and genetic characterization of viral gastroenteritis in hospitalized children aged <5 years in Yunnan Province, China, 2020-2022.
Front Pediatr
January 2025
Yunnan Provincial Key Laboratory of Public Health and Biosafety & Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, China.
Article Synopsis
- The study focused on the prevalence of various viruses causing acute gastroenteritis (AGE) in children under five years old in Yunnan, China.
- Over 610 stool samples were analyzed, revealing that rotavirus (RVA) was present in nearly 29% of the cases, with G8P[8] emerging as the dominant genotype in 2022.
- Norovirus was detected in about 12% of the samples, with GII.4 being the most common strain, while other viruses like sapovirus and human adenovirus had lower positivity rates.
- The results indicated higher AGE incidence in male children, particularly among those aged 12-23 months, with infection rates peaking in the early months of the year, highlighting
Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing.
Ital J Pediatr
January 2025
Department of Neonatology, Children's Hospital, Capital Institute of Pediatrics, Beijing, 100020, China.
Background: To explore the effect of non-pharmacological interventions (NPIs) on respiratory pathogen profiles among hospitalized infants aged 0-3 months in Beijing during the coronavirus disease 2019 (COVID-19) pandemic.
Methods: Respiratory specimens were collected from 1,184 infants aged 0-3 months who were hospitalized for acute respiratory infection at the Children's Hospital affiliated with the Capital Institute of Pediatrics from January 2018 to December 2023. The data were divided into three groups-the pre-epidemic (January 2018 to December 2019), epidemic prevention and control (January 2020 to December 2022), and post-epidemic (January 2023 to December 2023) groups-based on the outbreak of COVID-19 and the implementation and termination of NPIs.
Impact of COVID-19 pandemic measures on hospitalizations and epidemiological patterns of twelve respiratory pathogens in children with acute respiratory infections in southern China.
BMC Infect Dis
January 2025
Department of Respiratory, Shenzhen Children's Hospital, Shenzhen, 518038, China.
Objectives: To investigate the impact of COVID-19 pandemic measures on hospitalizations and the alterations and persistence of the epidemiological patterns of 12 common respiratory pathogens in children during the COVID-19 pandemic and after the cessation of the "zero-COVID-19" policy in southern China.
Methods: Respiratory specimens were collected from hospitalized children with acute respiratory infections at Shenzhen Children's Hospital from January 2020 to June 2024. Twelve common respiratory pathogens were detected using multiplex PCR.
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