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Controversies around the treatment of peritoneal metastases of colorectal cancer.
World J Gastrointest Oncol
January 2025
Department of General Surgery, Hospital General de Requena, Requena 46340, Spain.
In this editorial we examine the article by Wu published in the . Surgical resection for peritoneal metastases from colorectal cancer (CRC) has been gradually accepted in the medical oncology community. A randomized trial (PRODIGE 7) on cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal origin.
View Article and Find Full Text PDFApplication of Different Surgical Strategies in Helicobacter pylori-Associated Gastric Ulcers with Perforation: A Comparative Study of Short-Term and Long-Term Outcomes and Complication Risks.
Ann Ital Chir
January 2025
Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China.
Aim: This study compared the short- and long-term efficacy of simple suture with omental patch repair (Graham patch) in open surgery versus laparoscopic omental patch repair (LOPR) in treating patients with Helicobacter pylori (H. pylori)-associated gastric ulcers with perforation, and analyzed the incidence of complications.
Methods: The clinical information of patients who had stomach perforation repair surgery in Deqing People's Hospital between January 2021 and January 2022 was retrospectively analyzed.
Comparative evaluation of cellular senescence in naturally aged and stress-induced murine macrophages for identifying optimum senescent macrophage study systems.
Mol Biol Rep
January 2025
Faculty of Applied Sciences & Biotechnology, Shoolini University, Solan, 173229, India.
Background: The role and relevance of macrophages both as causes and therapeutics of cellular senescence is rapidly emerging. However, current knowledge regarding the extent and depth of senescence in macrophages in vivo is limited and controversial. Further, acute models of stress-induced senescence in transformed/cancerous macrophage cell lines are being used although their efficacy and relevance are not characterized.
View Article and Find Full Text PDFIntroduction-Aim: Spontaneous bacterial peritonitis (SBP) is a common complication in cirrhotic patients and is associated with a high mortality rate. The aim of this study is to determine the epidemiological and bacteriological profile of spontaneous bacterial peritonitis, as well as antibiotic resistance among hospitalized patients at CHU Mohammed VI, in order to guide empirical antibiotic choices for better management. Methods: This is a prospective study conducted over a period of 12 months, from January to December 2023, focusing on all requests for bacteriological examination of ascitic fluid samples.
View Article and Find Full Text PDFClinical Characteristics of and Treatment Pattern for EGFR-Amplified Colorectal Cancer.
Cancer Res Treat
January 2025
Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Purpose: To compare clinicopathologic features and clinical outcomes of metastatic colorectal cancer (mCRC) based on EGFR amplification status.
Materials And Methods: Patients with mCRC who underwent next-generation sequencing using a targeted 244-gene panel from 2016 to 2021 were identified and screened for EGFR copy numbers. Cases with at least 5 copies were reviewed for tumor purity adjustment, and those with an adjusted copy number of ≥6 were defined as EGFR-amplified (EGFR amp+).
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