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Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality.
Int J Biol Macromol
January 2025
School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, Yunnan, China. Electronic address:
Most Kunitz inhibitors exhibit serine protease inhibitory activity, but limited information is available on the regulation of platelet function. Herein, we report the purification and characterization of a novel single Kunitz domain inhibitor (Sibanin) from the salivary glands of the black fly Simulium bannaense. Recombinant Sibanin prolonged activated partial thromboplastin time and prothrombin time, and exhibited high-affinity binding to FXa and elastase with a KD of 5.
View Article and Find Full Text PDFExploring the morphine-platelet activity association in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Platelets
December 2024
Department of Cardiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Article Synopsis
- STEMI is typically triggered by a ruptured plaque, leading to blood clot formation, and treatments like platelet inhibitors and PCI are crucial for recovery.
- This study, part of the VALIDATE-SWEDHEART trial, analyzed 89 STEMI patients to examine how morphine, used for pain relief, affects platelet activity after treatment with ticagrelor and primary PCI.
- Results indicated that morphine treatment was associated with higher platelet aggregation one hour after PCI, but did not impact inflammation biomarkers or show significant differences before or twelve hours post-PCI.
Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro.
Int J Mol Sci
September 2024
Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45100 Ioannina, Greece.
The omega-3 polyunsaturated fatty acids (PUFAs) Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) exert multiple cardioprotective effects, influencing inflammation, platelet activation, endothelial function and lipid metabolism, besides their well-established triglyceride lowering properties. It is not uncommon for omega-3 PUFAs to be prescribed for hypertriglyceridemia, alongside antiplatelet therapy in cardiovascular disease (CVD) patients. In this regard, we studied the effect of EPA and DHA, in combination with antiplatelet drugs, in platelet aggregation and P-selectin and αβ membrane expression.
View Article and Find Full Text PDFFlufenamic acid abolishes epileptiform activity in the entorhinal cortex slices by reducing the temporal summation of glutamatergic responses.
Biochem Biophys Res Commun
November 2024
Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, pr. Torez 44, 194223, Saint Petersburg, Russia. Electronic address:
Flufenamic acid (FFA) is an anti-inflammatory drug that affects multiple targets and is a widely used research tool in ion channel studies. This pharmacological compound has a low level of selectivity for the transient receptor potential (TRP) channel superfamily, blocking calcium-activated nonselective cation current (I) as well as afterdepolarizations (ADP) induced by it. A number of studies have demonstrated that FFA exerts an anti-epileptic effect in vitro, although the precise mechanism of this effect is not yet identified.
View Article and Find Full Text PDFHalf-dose ticagrelor versus standard-dose clopidogrel in a dual antiplatelet regimen for stent-assisted coiling or flow diversion of unruptured intracranial aneurysms: a cohort study.
J Neurointerv Surg
August 2024
Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Article Synopsis
- Intracranial hemorrhage poses a significant risk with standard-dose ticagrelor in dual antiplatelet therapy for patients with unruptured intracranial aneurysms, leading researchers to explore a lower dose.
- A study compared the effects of half-dose ticagrelor and standard-dose clopidogrel in patients undergoing stent-assist coiling or flow diversion, measuring platelet aggregation and adverse events over six months.
- The results showed that half-dose ticagrelor had comparable antithrombotic effects and safety profiles to clopidogrel, suggesting it could be a viable alternative in managing these patients.
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