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Malian field isolates provide insight into Plasmodium malariae intra-erythrocytic development and invasion.
PLoS Negl Trop Dis
January 2025
Malaria Research and Training Center (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.
Plasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. Nevertheless, our comprehension of this parasite's biology remains limited, primarily due to its frequent co-infections with other species and the lack of a continuous in vitro culture system. To effectively combat and eliminate this overlooked parasite, it is imperative to acquire a better understanding of this species.
View Article and Find Full Text PDFAeruginosin 525 (AER525) from Cyanobacterium Sp. (KUCC C2): A New Serine Proteases Inhibitor.
Mar Drugs
November 2024
Department of Marine Biology and Biotechnology, University of Gdańsk, M. J. Piłsudskiego 46, PL-81378 Gdynia, Poland.
Aeruginosins (AERs) are one of the most common classes of cyanobacterial peptides synthesised through a hybrid non-ribosomal peptide synthase/polyketide synthase pathway. They have been found in , , /, and The presence of AER in isolated from the Curonian Lagoon was reported for the first time in our previous work. Here, the structure of aeruginosin 525 (AER525), isolated from sp.
View Article and Find Full Text PDFIdentification, Purification, and Characterization of Kunitz-Type Protease Inhibitors from White-Fleshed Dragon Fruit () and Red-Fleshed Dragon Fruit () Seeds as Novel Food Allergens.
J Agric Food Chem
October 2024
US Department of Agriculture, Agricultural Research Service, Pacific West Area, Western Regional Research Center, 800 Buchanan Street, Albany 94710, California, United States.
Article Synopsis
- Clinical reports suggest that dragon fruits can cause allergic reactions, but the specific allergens responsible are not well understood.
- This study identified two new allergens in dragon fruits by using techniques like LC-MS/MS and cDNA sequencing, leading to the production of recombinant allergens.
- The findings reveal that these allergens are Kunitz-type protease inhibitors, which show similar structural characteristics to natural allergens and are major triggers of allergy in sensitized individuals.
Structure and functional studies of Avt1, a novel peptide from the sea anemone Aulactinia veratra.
Biochim Biophys Acta Proteins Proteom
January 2025
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; ARC Centre for Fragment-Based Design, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Sea anemones are a rich source of peptide toxins spanning a diverse range of biological activities, typically targeting proteins such as ion channels, receptors and transporters. These peptide toxins and their analogues are usually highly stable and selective for their molecular targets, rendering them of interest as molecular tools, insecticides and therapeutics. Recent transcriptomic and proteomic analyses of the sea anemone Aulactinia veratra identified a novel 28-residue peptide, designated Avt1.
View Article and Find Full Text PDFProduction and biochemical and biophysical characterization of fibrinolytic protease of a Mucor subtilissimus strain isolated from the caatinga biome.
An Acad Bras Cienc
September 2024
Universidade Federal Rural de Pernambuco, Departamento de Morfologia e Fisiologia Animal, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.
Cardiovascular diseases, resulting from the deposition of clots in blood vessels, are the leading cause of death worldwide. Fibrinolytic enzymatic activity can catalyze blood clot degradation. Findings show that 36 fungal isolates recovered from Caatinga soils have the potential to produce fibrinolytic protease under submerged conditions.
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