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Circulating levels of adiponectin and AdipoR expression in peripheral blood mononuclear cells are associated with lower respiratory tract Infection.
Front Immunol
January 2025
Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Objective: The role of adiponectin (APN) in regulating inflammation is well recognized in metabolic disease, but the dysregulation of APN in lower respiratory tract infection (LRTI) remains controversial. We aimed to measure APN and its signaling receptors, adiponectin receptor (AdipoR), in peripheral blood mononuclear cells (PBMCs) from LRTI patients to explore their potential roles in the LRTI process.
Methods: A total of 99 LRTI patients from the Second Xiangya Hospital of Central South University were categorized into acute (n=35) and non-acute (n=64), and non-severe (n=62) and severe (n=37) groups.
Histopathology of incidental non-neoplastic findings in transgenic CByB6F1-Tg(HRAS)2Jic mice used in toxicity studies.
J Toxicol Pathol
January 2025
Labcorp Early Development Laboratories, Inc., 3635 Concorde Parkway, Suite 100, Chantilly, VA, 20151, USA.
This technical report presents a collection of illustrative images and concise descriptions of non-neoplastic microscopic findings noted in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice from 26-week-carcinogenicity studies. A unique finding in the Tg.
View Article and Find Full Text PDFSymmetrical Bis-Hydrazone Ligand-Based Binuclear Oxido/Dioxido-Vanadium(IV/V) Complexes: Synthesis, Reactivity, and Catalytic Applications for the Synthesis of Biologically Potent 2-Phenylquinazolin-4-(3)-ones.
Inorg Chem
January 2025
Grupo NanoToxGen, Centro Interdisciplinar de Química y Biología (CICA), Departamento de Química, Facultade de Ciencias, Universidade da Coruña, A Coruna 15071, Spain.
Symmetrical bis(hydrazone)-based ligands, Hdar(bhz) (), Hdar(fah) (), Hdar(nah) (), and Hdar(inh) () obtained from 4,6-diacetylresorcinol (Hdar) and different hydrazides [benzoylhydrazide (Hbhz), isonicotinoylhydrazide (Hinh), nicotinoylhydrazide (Hnah), and 2-furoylhydrazide (Hfah)], were used to prepare potassium salts of binuclear -[VO] complexes, {K(HO)}[(VO)dar(bhz)] (), {K(HO)}[(VO)dar(fah)] (), {K(HO)}[(VO)dar(nah)] (), and {K(HO)}[(VO)dar(inh)] (), and binuclear [VO] complexes, [{VO(MeOH)}dar(bhz)] (), [{VO(MeOH)}dar(fah)] (), [{VO(MeOH)}dar(nah)] (), and [{VO(MeOH)}dar(inh)] (). In the presence of warm MeOH/DMSO (4:1), changed to {K(HO)}[(VO)Hdar(nah)]DMSO (·DMSO). Single crystal XRD studies of and confirm a binuclear structure along with a distorted square pyramidal geometry of each vanadium center where bis{ONO(2-)} ligands coordinate through phenolate-O, azomethine-N, and enolate-O atoms of each unit.
View Article and Find Full Text PDFRAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective.
BMC Res Notes
January 2025
Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Alborz, Iran.
Adult T-cell leukemia/lymphoma (ATLL) is a type of blood cancer related to human T-cell lymphotropic virus type 1 (HTLV-1). The principal aim of this study was to investigate cellular processes related to innate immune response, intracellular protein transport, and translational initiation regulation in individuals afflicted with ATLL and Acute lymphoblastic leukemia (ALL). Whole blood samples and peripheral blood mononuclear cells were collected from 10 viral ATLL patients and 10 ALL subjects.
View Article and Find Full Text PDFGenetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.
BMC Med
January 2025
Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Background: Current research underscores the need to better understand the pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). This study aimed to identify key targets involved in the progression of IPF.
Methods: We employed Mendelian randomization (MR) with three genome-wide association studies and four quantitative trait loci datasets to identify key driver genes for IPF.
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