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Decreased cardio-respiratory information transfer is associated with deterioration and a poor prognosis in critically ill patients with sepsis.
J Appl Physiol (1985)
January 2025
Network Physiology Lab, Division of Medicine, UCL, London, United Kingdom.
Article Synopsis
- Assessing illness severity in ICU patients is vital for predicting deterioration and prognosis, but traditional methods often disregard the interconnectedness of organ systems.
- This study introduced a novel approach using transfer entropy (TE) to analyze the information flow between heart rate, respiratory rate, and oxygen saturation in sepsis patients, hypothesizing a correlation between TE and patient outcomes.
- Findings indicated that specific patterns of information flow were linked to reduced mortality and lower risk of deterioration, emphasizing that physiological network mapping could effectively indicate illness severity in critically ill patients.
Modeling Patient-specific Apnea-bradycardia Patterns in Preterm Newborn.
IEEE Trans Biomed Eng
October 2024
Objective: Preterm infants are particularly exposed to severe cardio-respiratory events, associating apnea with bradycardia and oxygen desaturation. A patient-specific and event-specific model-based approach is proposed in this work to analyze the acute heart rate response to apnea-bradycardia events in preterm newborn.
Methods: A novel model integrating the main cardio-respiratory interactions which are specific to the neonatal period is proposed.
Severe Anaphylaxis From Remimazolam in a Mastocytosis Cancer Patient: A Case Report.
Cureus
September 2024
Department of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, USA.
Remimazolam besylate is a novel, rapid-onset, ultra-short-acting benzodiazepine with an advantageous cardio-respiratory safety profile. To date, there have been few published reports of remimazolam-induced anaphylaxis, none of which are documented in patients with mast cell disease. We describe the case of a 77-year-old male with oncologic mastocytosis who developed anaphylaxis following remimazolam administration.
View Article and Find Full Text PDFOutcomes of adolescent children with severe cardiogenic shock referred for extracorporeal membrane oxygenation: insight from collaboration of adult shock team and paediatric cardiac critical care.
Cardiol Young
October 2024
Paediatric Intensive Care, Paediatric Cardio-Respiratory Intensive Care Division, Royal Brompton Hospital, Guy's and St Thomas NHS Foundation Trust, London, UK.
Article Synopsis
- Adolescents in severe cardiogenic shock can be treated in both pediatric and adult medical centers.
- Six adolescent patients underwent expedited extracorporeal membrane oxygenation (ECMO) consultations, with support from an adult healthcare team, including transfers using ECMO.
- After receiving conventional treatment or ECMO, all patients showed good recovery with positive neurological outcomes.
Role of ATG4 Autophagy-Related Protein Family in the Lower Airways of Patients with Stable COPD.
Int J Mol Sci
July 2024
Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Section of Pathology, University of Messina, 98125 Messina, Italy.
Autophagy is a complex physiological pathway mediating homeostasis and survival of cells degrading damaged organelles and regulating their recycling. Physiologic autophagy can maintain normal lung function, decrease lung cellular senescence, and inhibit myofibroblast differentiation. It is well known that autophagy is activated in several chronic inflammatory diseases; however, its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and the expression of autophagy-related genes (ATGs) in lower airways of COPD patients is still controversial.
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