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Immune haemolysis was studied with the two types of genetically controlled sheep erythrocytes (E) which contain either high potassium (K) and low sodium (Na) (HK E) or low K and high Na (LK E). It was found that the susceptibility of HK and LK E to lysis by guinea-pig and human complement is influenced by the cationic environment. In veronal buffer containing 0.
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