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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria.
Nat Commun
December 2024
Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Conjugative plasmids promote the dissemination and evolution of antimicrobial resistance in bacterial pathogens. However, plasmid acquisition can produce physiological alterations in the bacterial host, leading to potential fitness costs that determine the clinical success of bacteria-plasmid associations. In this study, we use a transcriptomic approach to characterize the interactions between a globally disseminated carbapenem resistance plasmid, pOXA-48, and a diverse collection of multidrug resistant (MDR) enterobacteria.
View Article and Find Full Text PDFFrom Traditional to Cutting-Edge: Transforming Pulmonary Valve Assessment With Advanced Echocardiography Techniques.
Echocardiography
January 2025
Department of Cardiology, German Heart Center Charité, Berlin, Germany.
The pulmonary valve (PV), although often less emphasized than other heart valves, is crucial for cardiac function and hemodynamics. Historically, the PV has been underrepresented in echocardiographic assessments due to its rare involvement in pathological conditions, particularly in adults. Additionally, the anatomical position of the PV makes it one of the most challenging valves to visualize using conventional echocardiography.
View Article and Find Full Text PDFAlgorithmic individual fairness and healthcare: a scoping review.
JAMIA Open
February 2025
Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Objectives: Statistical and artificial intelligence algorithms are increasingly being developed for use in healthcare. These algorithms may reflect biases that magnify disparities in clinical care, and there is a growing need for understanding how algorithmic biases can be mitigated in pursuit of algorithmic fairness. We conducted a scoping review on algorithmic individual fairness (IF) to understand the current state of research in the metrics and methods developed to achieve IF and their applications in healthcare.
View Article and Find Full Text PDFAn Unexpected Evolution: Severe Pneumonia in an Immunocompromised Patient.
Cureus
December 2024
Critical Care, Unidade Local de Saúde de Braga, Braga, PRT.
Community-acquired pneumonia (CAP) varies in clinical presentation, ranging from mild pneumonia characterized by fever and productive cough to severe pneumonia characterized by respiratory distress and sepsis. We present a 40-year-old woman who presents to the emergency room with dyspnea, pleuritic chest pain, productive cough with hemoptysis, and fever. On physical examination, the patient presents with tachypnea and hypotension, which proved refractory to fluid therapy.
View Article and Find Full Text PDFMolecular identification of species from pneumonic goats, Iraq.
Open Vet J
November 2024
Department of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, University of Wasit, Wasit, Iraq.
Background: In goats, acute and chronic respiratory infections are often characterized by a rapidly progressing clinical course with little opportunity to develop an effective antibiotic therapy.
Aim: This study aimed to identify spp. in pneumonic goats, assess its antibiotic susceptibility, and confirm the molecular phylogenetics of spp.
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