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LPO products were measured in plasma and biogenic amines (serotonin, adrenalin, noradrenalin) in tissues of rats in different periods after hemorrhagic shock provoked by taking blood and maintenance of arterial pressure at the level of 40 mm Hg for 1 hour. Resuscitation was conducted by administration of autoblood. It was found that splenic serotonin levels decreased on experiment day 7 and went up on day 28.
View Article and Find Full Text PDFFacilitation and feedback in the hypothalamo-pituitary-adrenal axis during food restriction in rats.
J Neuroendocrinol
December 1993
Stress et Physiopathologie de l'Adaptation, INSERM U259-INRA, Université de Bordeaux II, France.
After 4 weeks of food restriction to 50% of ad libitum intake in rats, plasma corticosterone levels were increased, without any change in adrenal weight, and with no evidence of sympathetic nervous system activation (as measured by Tyrosine Hydroxylase and Phenylethanolamine N-Methyl Transferase activities in the adrenal gland). Plasma corticosterone levels were normalized wih the addition of 35% of the calories as sugar. The adrenocortical axis activity was therefore investigated in more detail (nycthemeral cycle of corticosterone levels, ACTH and corticosterone response to a CRF challenge) in ad libitum fed rats and in animals fed 85% or 50% of the intake of the control animals, just before switching the lights off in order to maintain the diurnal rhythm of food intake.
View Article and Find Full Text PDFInfluence of social environment and of drugs on 3H-corticosterone uptake in various brain areas.
Ann Ist Super Sanita
December 1979
Through specific cytoplasmic-nuclear receptors, brain appears as a target tissue for corticosteroids in their affecting neuroendocrine and behavioural activities. 3H-corticosterone (3H-B) uptake in various brain areas of differentially reared mice was studied in order to ascertain possible differences which might be connected to the different patterns of behavioural, neurochemical and stress responses. In 4-day adrenalectomized mice 1-h 3H-B uptake was higher in grouped than in isolated ones.
View Article and Find Full Text PDFLaboratory experimentation has demonstrated the large increase in the rate of circulating norepinephrin (N.E.), in a parallel with an improvement in cardiovascular dynamism of suprarenalectomized rabbits under the action of injection IV of hydrocortisone.
View Article and Find Full Text PDFThe adrenocortical function was studied in 23 patients with hyperthyroidism and compared with a group of 15 normal subjects. Parameters of adrenal function were determined with 1,2(3)H-cortisol. The half-life of cortisol is significantly shortened in hyperthyroidism, as compared to normal subjects (49,5 +/- 6,6 min vs 68,3 +/- 10,5 min) and metabolic clearance rate is increased (418,5 +/- 89,5 L/24 h vs 237,5 +/- 48,5 L/24 h, for normal subjects).
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