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Drug Reaction With Eosinophilia and Systemic Symptoms Secondary to Trimethoprim/Sulfamethoxazole: A Case Report.
Cureus
November 2024
Emergency Medicine, Memorial Healthcare System, Hollywood, USA.
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a rare and potentially life-threatening condition. Symptoms typically manifest two to eight weeks after exposure to an offending agent, such as anticonvulsants and antibiotics. Clinical features include fever, morbilliform rash, eosinophilia, lymphadenopathy, and, in severe cases, multiorgan dysfunction, including interstitial nephritis, hepatitis, and pneumonitis.
View Article and Find Full Text PDFThe emerging role of alarmin-targeting biologics in the treatment of patients with COPD.
Chest
December 2024
Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Topic Importance: Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous lung disease characterized by persistent airflow limitation secondary to airways and parenchymal abnormalities, and respiratory symptoms, including dyspnoea, fatigue, chronic cough, and sputum production. Cigarette smoke exposure is a major contributor to COPD although inhalation of toxic particles and other environmental and host factors can contribute to its genesis. Over time, the clinical course is frequently punctuated by exacerbations that further accelerate lung function decline and increase exacerbation risk.
View Article and Find Full Text PDFImpact of Individual Characteristics on Hospital Outcomes in Exacerbated COPD in a Biomass-Exposed Turkish Population.
J Clin Med
November 2024
Department of Medical Oncology, Akdeniz University, 07070 Antalya, Türkiye.
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is a major global health issue, and factors like biomass exposure, patient demographics, and other health conditions play a significant role in worsening patient outcomes during episodes of exacerbation.
- A study analyzed medical records of 334 COPD patients from January 2021 to December 2023, focusing on how biomass exposure influences hospital outcomes like ICU admissions, length of stay, and in-hospital mortality, rather than looking at its direct effects.
- Results showed that patients with biomass exposure were more likely to be female, had lower smoking rates, and experienced higher ICU admissions and mortality; older patients also faced greater health challenges during their hospital stays, although specific characteristics didn't significantly correlate with outcomes.
Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma.
J Allergy Clin Immunol
November 2024
Department of Medicine, Duke University Medical Center, Durham, NC.
Background: Airway tissue eosinophilia can be an observed feature of obesity-associated type 2 (T2) asthma, but the processes mediating this inflammation are unknown.
Objective: To investigate a process whereby leptin, an adipokine elevated in obesity, potentiates pulmonary eosinophilia and eotaxin production by airway fibroblasts in T2 asthma.
Methods: We assessed associations between body mass index and airway eosinophilia as well as leptin and eotaxin production in 78 participants with asthma, 36 of whom exhibited obesity.
Carbimazole-induced eosinophilic gastroenteritis in a young female with abdominal pain and ascites: a case report.
J Med Case Rep
November 2024
Dubai Academic Health Corporation, Rashid Hospital, Oudh Metha Road, P. O. Box 44220, Dubai, UAE.
Background: Eosinophilic gastroenteritis is a rare disease characterized by eosinophilic infiltration into one or more layers of the gastrointestinal tract. It commonly affects children more than adults. The clinical features depend on the site of gut involvement, but the most common symptoms include abdominal pain and diarrhea.
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