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Effect of fezolinetant on patient-reported quality-of-life outcomes: Data from a phase 3b study (DAYLIGHT) of the treatment of moderate to severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy.
Maturitas
November 2024
Hormone Hamburg, Hamburg, Germany. Electronic address:
Objective: To report patient-reported quality-of-life (QOL) outcomes in the DAYLIGHT study.
Study Design: DAYLIGHT was a phase 3b, randomized, double-blind, 24-week, placebo-controlled study. Participants were women aged ≥40 to ≤65 years with moderate to severe vasomotor symptoms (VMS) considered unsuitable for hormone therapy (HT) (contraindications, caution, stoppers, or averse) randomized 1:1 to placebo or fezolinetant 45 mg once daily.
The microbiota of cork and yellow stain as a model for a new route for the synthesis of chlorophenols and chloroanisoles from the microbial degradation of suberin and/or lignin.
Microbiome
January 2025
Instituto de Investigación de La Viña y El Vino, Escuela de Ingeniería Agraria, Universidad de León, Avenida de Portugal, 41, León, 24009, Spain.
Article Synopsis
- Cork is primarily used for wine bottle stoppers, but it can contain 2,4,6-trichloroanisole, which causes a musty odor that negatively affects wine quality and leads to financial losses.
- The presence of yellow stain in cork indicates a degradation linked to higher microbial populations, particularly filamentous fungi that break down lignin, and this microbiota contributes to the formation of chlorophenols and chloroanisoles.
- Research identified specific fungal and bacterial species associated with yellow stain and demonstrated that certain strains can convert p-hydroxybenzoate into phenol, which can then be chlorinated, potentially leading to the development of 2,4,6-trichlorophenol.
Deloyers Technique for Restoration of Bowel Continuity Following Extended Left Hemicolectomy: A Comprehensive Analysis of 97 Cases and Literature Review.
Dis Colon Rectum
December 2024
Department of Colorectal Surgery, Cleveland Clinic, Ohio, United States.
Background: Deloyers technique addresses challenges in restoring bowel continuity following extended left hemicolectomies. Despite being first described in 1958, the technique remains underutilized, with limited data on long-term outcomes.
Objective: To evaluate the indications, surgical and functional outcomes of Deloyers technique and review existing literature.
Securing the Puncture Depth via an Endodontic Stopper in Arthrocentesis of the Temporomandibular Joint: A Technical Note.
Int J Oral Maxillofac Surg
January 2025
Christian Albrecht's University, Department of Oral and Maxillofacial Surgery, Arnold-Heller-Straße 3, Haus B, UKSH, 24105 Kiel, Germany.
The reported complications after arthrocentesis of the temporomandibular joint are rare, which makes it to an outpatient and safe oral and maxillofacial surgical procedure. A penetration into the middle cranial fossa is an extremely rare but serious complication for the conventional needle arthrocentesis. The simple technical modification described herein could help to easily retain the puncture depth via an endodontic silicone stopper to avoid this rare complication.
View Article and Find Full Text PDFFeculent Drainage from Percutaneous Endoscopic Gastrostomy Tube due to Gastrocolocutaneous Fistula Found in Emergency Department: A Case Report.
Clin Pract Cases Emerg Med
November 2024
Loma Linda University Medical Center, Department of Emergency Medicine, Loma Linda, California.
Article Synopsis
- Percutaneous endoscopic gastrostomy (PEG) placement is a routine procedure for patients needing non-oral feeding, but it can lead to rare complications like gastrocolocutaneous fistula, where the bowel is caught during placement.
- A 73-year-old male on hospice experienced malodorous leakage from his PEG tube months after placement, prompting an emergency department visit where imaging revealed the tube was incorrectly positioned in the transverse colon.
- The patient was treated non-surgically by removing the PEG tube and switching to a nasogastric tube for nutrition, highlighting the need for careful tube management and awareness of potential complications such as gastrocolocutaneous fistula in similar cases.
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