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Optimization of the ductile properties of poly(lactic acid) (PLA) using green citrate-based plasticizers and itaconic anhydride grafted PLA (PLA-g-IA).
Int J Biol Macromol
March 2025
Instituto Universitario de Investigación de Tecnología de Materiales (IUITM), Universitat Politècnica de València (UPV), Plaza Ferrándiz y Carbonell 1, 03801 Alcoy, Alicante, Spain. Electronic address:
Certain miscellaneous beans have a low glycemic index (GI) and may reduce the risk of chronic metabolic disorders, including type 2 diabetes and obesity, by modulating postprandial glucose homeostasis and blood lipid levels. In this study, red kidney bean flour and wheat gluten were used as raw materials, and long-chain inulin phosphate monoester (PFXL) was added to improve the quality of red kidney bean dough, prepare high-quality steamed bread, and explore its health effect on type 2 diabetes. The results showed that the addition of PFXL improved the water distribution and rheological properties of coarse grain dough and enriched the flavor of coarse grain steamed bread.
View Article and Find Full Text PDFHybrid membranes-mediated biomimetic-nanoparticle carrying miR-665 for effective tumor treatment by remodeling tumor microenvironment.
Int J Pharm
March 2025
Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, PR China. Electronic address:
Background: Osteosarcomas (OS) are malignant bone tumors prevalent in adolescents, characterized by aggressiveness and early metastasis. Current treatments including surgery and chemotherapy face challenges due to drug limitations and the complex tumor microenvironment (TME).
Methods: Tumour membranes (TM) derived from OS cells and macrophage membranes (MM) derived from macrophages were mixed to create hybrid membranes (HM), which were subsequently used to encapsulate microRNA-665(miR-665)-loaded Poly lactic-co-glycolic acid (PLGA) nanoparticles, forming HM@PLGA/miR-665 complexes.
CircRUNX1 enhances the Warburg effect and immune evasion in non-small cell lung cancer through the miR-145/HK2 pathway.
Cancer Lett
March 2025
Department of Thoracic Surgery, Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, Nantong 226001, China. Electronic address:
Non-small cell lung cancer (NSCLC) is acknowledged as the primary subtype of lung cancer. The Warburg effect, marked by elevated glucose consumption and lactate fermentation, is a prevalent characteristic of NSCLC. The mechanisms by which circRNA mediates the regulation of the Warburg effect and immune evasion in NSCLC remain unclear.
View Article and Find Full Text PDFEffective-compounds of Jinshui Huanxian Formula acts as an SRC inhibitor to inhibit HK2-mediated H3K18 lactation and improve pulmonary fibrosis.
Phytomedicine
March 2025
Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry of P.R. China, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450000, China. Electronic address:
Background: The Active Ingredient Composition of Jinshui Huanxian Formula (ECC-JHF) consists of five active ingredients: icariin, isoliquiritigenin, nobiletin, peimine, and paeoniflorin, which demonstrate notable therapeutic effects on pulmonary fibrosis.
Purpose: Inhibition of glycolysis has been demonstrated to be effective in treating experimental idiopathic pulmonary fibrosis (IPF). This research seeks to explore the impact of aerobic glycolysis on the mitigation of pulmonary fibrosis through ECC-JHF.
Long-term monitoring of biofilm succession unveils differences between biodegradable and conventional plastic materials.
Mar Pollut Bull
March 2025
Polymers and Advanced Materials Group (PIMA), Universitat Jaume I (UJI), Av. de Vicent Sos Baynat s/n, Castelló de la Plana, Castelló 12071, Spain. Electronic address:
A vast amount of plastic waste enters the ocean every year and the Mediterranean Sea is particularly affected by this issue. Biodegradable polymers like poly(lactic acid) (PLA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), may help mitigate this problem. We investigated bacterial biofilm development and succession on these polymers over one year in the Western Mediterranean Sea.
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