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HPA-Axis Activity and Nutritional Status Correlation in Individuals with Alcohol Use Disorder.
Nutrients
November 2022
Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.
Impaired activity of the hypothalamic-pituitary-adrenal axis (HPA-axis) is evident in alcohol use disorder (AUD), and may be implicated in various nutritional and metabolic alterations often seen in individuals with this disorder. The present study examined a possible correlation between HPA-axis activity and nutritional status components in individuals with AUD. Fourteen AUD and fourteen non-AUD males participated; anthropometric and body composition measurements were made, and fasting blood samples were analysed for plasma adrenal corticotropic hormone (ACTH), catecholamines, cortisol and beta-endorphin.
View Article and Find Full Text PDFDiagnostic accuracy of bilateral inferior petrosal sinus sampling using desmopressin or corticotropic- releasing hormone in ACTH-dependent Cushing's syndrome: A systematic review and meta-analysis.
Rev Endocr Metab Disord
October 2022
Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study evaluates the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) for Cushing's syndrome (CS) using either desmopressin (DDAVP) or corticotropin-releasing hormone (CRH) due to a shortage of CRH.
- A systematic review of 11 studies involving 612 participants showed that both DDAVP and CRH provided high sensitivity (96% for DDAVP, 98% for CRH) and specificity (both 1.00), indicating their effectiveness for diagnosis.
- The findings suggest that DDAVP is a safe, cost-effective alternative to CRH for BIPSS in diagnosing Cushing's syndrome across all age groups.
[Fatal outcome of Netherton syndrome due to excessive use of topical corticosteroids in an adult patient].
Ann Dermatol Venereol
January 2020
Hôpital Larrey, 24, chemin de Pouvourville, 31400 Toulouse, France.
Introduction: Netherton syndrome (NS) is a rare disease caused by SPINK5 mutations associated with ichthyosis (erythroderma and desquamation), alopecia and atopic manifestations. There are no effective treatments. Topical corticosteroids may be used for a limited period in the event of eczema.
View Article and Find Full Text PDFRole of the ubiquitin/proteasome system on ACTH turnover in rat corticotropes.
Endocrine
September 2018
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Cusano Milanino (Milan), Milan, Italy.
Purpose: A large number of studies has investigated proopiomelanocortin processing in anterior pituitary corticotropes but little is known on proopiomelanocortin/ACTH degradation within these cells. The ubiquitin-proteasome system is an intracellular protein degradation pathway which has garnered considerable interest in recent times, given its role in maintenance of protein homeostasis. Aim of the present study was to evaluate the role of the ubiquitin-proteasome system in proopiomelanocortin/ACTH turnover in pituitary corticotropes.
View Article and Find Full Text PDFGroup 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality.
Ann Endocrinol (Paris)
December 2017
Service des maladies endocriniennes et métaboliques, hôpital Cochin, CHU Paris Centre, 75014 Paris, France.
The prevalence of primary adrenal insufficiency is estimated at between 82-144/million, with auto-immunity being the most common cause in adults and genetic causes, especially enzyme defects, being the most common cause in children. The prevalence of secondary adrenal deficiency is estimated to be between 150-280/million. The most frequent occurrence is believed to be corticosteroid-induced insufficiency, despite the incidence of clinically relevant deficiency after cessation of glucocorticoid treatment being widely debated.
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