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Cognitive control in individuals with heroin use disorder after prolonged methadone maintenance treatment.
BMC Psychiatry
January 2025
School of Mental Health, Bengbu Medical University, Bengbu, Anhui, 233030, China.
Background: Although impaired cognitive control is common during the acute detoxification phase of substance use disorders (SUD) and is considered a major cause of relapse, it remains unclear after prolonged methadone maintenance treatment (MMT). The aim of the present study was to elucidate cognitive control in individuals with heroin use disorder (HUD) after prolonged MMT and its association with previous relapse.
Methods: A total of 63 HUD subjects (41 subjects with previous relapse and 22 non-relapse subjects, mean MMT duration: 12.
A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds.
Animal
December 2024
University of Molise, Department of Agricultural, Environmental and Food Science, Campobasso, Italy.
In sheep, gastrointestinal nematodes (GINs) can cause disease, reduced feed intake, and nutritional deficiencies. To counteract GINs, anthelmintics are widely used although it is well known they may enter the environment impacting ecosystems. In addition, anthelmintics resistance has rapidly developed and consequently, alternative approaches are crucial for profitable and sustainable sheep production.
View Article and Find Full Text PDFGrowth inhibition by ppc deletion is rescued by isocitrate dehydrogenase mutations in Escherichia coli.
FEMS Microbiol Lett
January 2025
Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka 565-0871, Japan.
Phosphoenolpyruvate carboxylase encoded by ppc catalyzes the anaplerotic reaction of oxaloacetate in the TCA cycle in Escherichia coli. Deletion of ppc does not prevent the cells from replenishing oxaloacetate via the glyoxylate shunt, but the ppc-deletion strain almost did not grow on glucose. In the present study, we obtained evolved strains by deleting both ppc and mutS to increase the mutation rate and investigated the mechanisms for improving growth by analyzing the mutated genes.
View Article and Find Full Text PDFAsGAD1 cloned from creeping bentgrass modulates cadmium tolerance of Arabidopsis thaliana by remodelling membrane lipids and cadmium uptake, transport and chelation.
Physiol Plant
January 2025
College of Grassland Science and Technology, Sichuan Agricultural University, Chengdu, China.
The gene GAD1 encodes a glutamate decarboxylase, which is a rate-limiting enzyme for the biosynthesis of endogenous γ-aminobutyrate acid (GABA), but a potential role of GAD1 in regulating cadmium (Cd) tolerance needs to be further elucidated in plants. The objective of this study was to investigate Cd tolerance of creeping bentgrass (Agrostis stolonifera) and transgenic yeast (Saccharomyces cerevisiae) or Arabidopsis thaliana overexpressing AsGAD1. The Cd-tolerant creeping bentgrass cultivar LOFTSL-93 accumulated more endogenous GABA in relation to a significant upregulation of AsGAD1 in leaf and root than the Cd-sensitive W66569 in response to Cd stress.
View Article and Find Full Text PDFMicrobial mechanism for improving biogas production performance from boiling acidified pig manure feedstock.
Bioresour Technol
January 2025
Huanghe Science and Technology College, No. 94 Hanghai Middle Road, Zhengzhou 450000, PR China.
A short heat treatment (HT, 90 °C-100 °C, 5 min) was applied to two-phase anaerobic digestion (TPAD) of pig manure (PM) to investigate its effect on microbial inactivation in the acidified feedstock during the methanogenic phase. The results showed that no differences in biogas production at organic loading rate (OLR) below 4.28 g volatile solid (VS)/(L·d).
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