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Which fluoroquinolone is safer when combined with bedaquiline for tuberculosis treatment: evidence from FDA Adverse Event Reporting System database from 2013 to 2024.
Front Pharmacol
December 2024
Department of Infectious Disease, Shaoyang Central Hospital, Shaoyang, China.
Objective: To investigate which fluoroquinolone is safer when combined with bedaquiline for tuberculosis treatment by using the FDA Adverse Event Reporting System (FAERS) database.
Methods: We selected data from the first quarter (Q1) of 2013 to the second quarter (Q4) of 2024 from the FDA FAERS database for disproportionality analysis. Signal detection was conducted using the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM).
Particularities of Pyelonephritis With Multidrug-Resistant (MDR) Germs During Pregnancy: A Case-Control Study.
Cureus
October 2024
Department of Urology, Grigore T. Popa University of Medicine and Pharmacy, Iasi, ROU.
Introduction: The aim of this study was to analyze the characteristics of pyelonephritis with multidrug-resistant (MDR) bacteria in pregnant women in comparison to pyelonephritis with multidrug-sensitive bacteria in this particular patient group.
Methods: We conducted a retrospective study over a period of three years on a study group of 17 pregnant patients with pyelonephritis with MDR bacteria and on a control group of 52 pregnant patients with pyelonephritis with multidrug-sensitive bacteria. We analyzed the demographic data, the potential risk factors, aspects of the clinical picture, the incidence and type of bacteria involved, and their sensitivity spectrum.
Renal jejunal fistula with worm infestation: A rare case report from a pediatric patient.
Int J Surg Case Rep
December 2024
Rehman Medical Institute, Department of Surgery, Peshawar, Pakistan.
Introduction And Importance: This case report details a rare instance of a renal jejunal fistula accompanied by tuberculosis (TB) and parasitic infestation in a pediatric patient. It adds to the limited literature on renal fistulas involving the jejunum, particularly those compounded by infectious diseases, highlighting the diagnostic and therapeutic challenges in managing such complex cases.
Case Presentation: The patient initially presented with flank pain, a discharging sinus in the left flank region, cough, and general malaise, alongside symptoms of anemia.
Xanthogranulomatous Pyelonephritis and Plummer-Vinson Syndrome: A Case Report Exploring Potential Connections in a Single Patient.
Cureus
September 2024
General Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- - Xanthogranulomatous pyelonephritis (XGP) mimics cancer and is a severe kidney infection, while Plummer-Vinson Syndrome (PVS) is characterized by swallowing difficulties, low iron levels, and esophageal webs.
- - A case study of a 53-year-old woman with past kidney stones who exhibited symptoms indicating both XGP and PVS underscores the complexity of diagnosing these overlapping conditions.
- - The case illustrates the importance of a multidisciplinary approach for accurate diagnosis and management, highlighting the links between chronic infections, malnutrition, and the development of neoplasms.
Anti-IL12p40 autoantibodies in a teenage girl with multiple recurrent abscesses.
Clin Immunol
September 2024
Immune deficiencies Lab, National Institute of Pediatrics, Mexico City, Mexico. Electronic address:
More frequent among adults, phenocopies may be caused by somatic mutations or anti-cytokine autoantibodies, mimicking the phenotypes of primary immunodeficiencies. A fourteen-year-old girl was referred for a two-year history of weight loss and multiple recurrent abscesses, complicated recurrent pneumonia, pyelonephritis, osteomyelitis, and septic shock, without fever. She had started with nausea, hyporexia, and weight loss, then with abscesses in her hands, knee, ankle, and spleen.
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