A new multiparameter method for evaluating anxiety-phobic states in rats is elaborated. The method is based on the ranged scale consisting of parameters which characterize the species-specific rat response to the series of ethologically adequate test-stimuli inducing manifestation of the anxiety-phobic states. The method makes it possible to evaluate individual anxiety-phobic level in rats, to form experimental groups with rats of known individual anxiety-phobic level, to conduct repeated observations in the same animals. The method is easy to perform in laboratory and makes it possible to get the results quickly.
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Exploring the impact of trauma-adapted yoga in forensic psychiatry.
Psychiatry Res
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Department of Health Sciences, University West, 461 86 Trollhättan, Sweden; Centre for Holistic Psychiatry Research (CHoPy), 431 60 Mölndal, Sweden. Electronic address:
The specialized field of forensic psychiatry deals with the care of criminal offenders who suffer from severe mental disorders. As this field is positioned at the intersection of illness, crime, and security, it poses complex challenges. While high-quality clinical studies in forensic psychiatry settings are limited, recent investigations have suggested yoga as a complementary clinical tool within correctional environments.
View Article and Find Full Text PDF[Experience of clinical use of fluvoxamine for the treatment of comorbid depression in childhood and adolescence].
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Mental Health Research Center, Moscow, Russia.
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Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders.
Cell Rep Med
September 2022
Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Institute of Genomics and Systems Biology, The University of Chicago, Chicago, IL 60637, USA; Department of Human Genetics and Committee on Quantitative Methods in Social, Behavioral, and Health Sciences, The University of Chicago, Chicago, IL 60637, USA. Electronic address:
In complex diseases, the phenotypic variability can be explained by genetic variation (G), environmental stimuli (E), and interaction of genetic and environmental factors (G-by-E effects), among which the contribution G-by-E remains largely unknown. In this study, we focus on ten major neuropsychiatric disorders using data for 138,383 United States families with 404,475 unique individuals. We show that, while gene-environment interactions account for only a small portion of the total phenotypic variance for a subset of disorders (depression, adjustment disorder, substance abuse), they explain a rather large portion of the phenotypic variation of the remaining disorders: over 20% for migraine and close to or over 30% for anxiety/phobic disorder, attention-deficit/hyperactivity disorder, recurrent headaches, sleep disorders, and post-traumatic stress disorder.
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