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Cardiovascular effects of early maternal separation and escitalopram treatment in rats with depressive-like behaviour.
Auton Neurosci
December 2024
Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Paraná, Brazil.
Depression and cardiovascular diseases are two of the world's major health problems. Escitalopram (ESC) is widely used because of its safety in relation to other drugs in that class; however, it can affect the cardiovascular system. The present study evaluated the cardiovascular parameters of depressive-like male rats and the cardiovascular effects of ESC treatment on that condition.
View Article and Find Full Text PDFScoping Review: Is Push-Dose Norepinephrine a Better Choice?
West J Emerg Med
September 2024
Morristown Medical Center, Sameth Emergency Department, Morristown, New Jersey.
Introduction: The use of push-dose vasopressors to treat anesthesia-induced hypotension is a common evidence-based practice among anesthesiologists. In more recent years, the use of push-dose vasopressors has transitioned to the emergency department (ED) and critical care setting. There is debate on the best choice of a push-dose vasopressor, with push-dose epinephrine or phenylephrine being more commonly used.
View Article and Find Full Text PDFReappraisal of the mechanism of cardiovascular responses to sympathomimetic amines in anaesthetised rats: dual α-adrenoceptor and trace amine receptor mechanisms.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Division of Pharmacology, Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward Vll Avenue, Cathays Park, Cardiff, Wales, CF10 3NB, UK.
Established dogma is that sympathomimetic amines, including β-phenylethylamine (PEA), increase blood pressure by releasing noradrenaline from sympathetic neurons. Recent evidence allowing longer contact with isolated immersed tissues indicates other mechanisms. The present study re-evaluates the mechanism of pressor responses to PEA in anaesthetised rats with longer exposure to infusions.
View Article and Find Full Text PDFPathophysiologic Vasodilation in Cardiogenic Shock and Its Impact on Mortality.
Circ Heart Fail
September 2024
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (M.A.C., M.A., C.P.K., M.S., E.D., I.T., J.L., B.K., J.G., M.G., C.H.S., J.E.T., J.C.F., S.G.D., T.C.H.).
Background: Cardiogenic shock (CS) mortality remains near 40%. In addition to inadequate cardiac output, patients with severe CS may exhibit vasodilation. We aimed to examine the prevalence and consequences of vasodilation in CS.
View Article and Find Full Text PDFThe stimulant cathine from Khat causes tachycardia indirectly in the rat.
Basic Clin Pharmacol Toxicol
September 2024
Department of Clinical Physiology, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Leaves of the Khat plant are widely consumed in the Horn of Africa, Yemen and the Jazan region of Saudi Arabia. I have investigated the mode of cardiovascular and autonomic actions of the stimulant cathine from Khat in terms of direct or indirect adrenergic actions in anaesthetised male and female rats, and in isolated tissues. Male and female rats were anaesthetised with pentobarbitone and changes in diastolic blood pressure and cardioaccelerator responses were examined in vehicle-treated or chemically sympathectomised rats.
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