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The Effect of Face Mask Wear on the Ocular Surface and Contact Lens Microbiome.
Eye Contact Lens
November 2024
School of Optometry and Vision Science (J.O., M.K., M.W.), University of New South Wales, Sydney, Australia; Host-Microbiome Interactions Group (M.E.M.), School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia; Department of Ophthalmology (M.C.), Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney, Australia; and School of Biological (J.O., T.T.), Earth and Environmental Sciences, University of New South Wales, Sydney, Australia.
Objectives: As face mask wear can result in the redirection of nasal and oral exhalation toward the ocular region, this study investigated the impact of face mask wear on the conjunctiva, eyelid margin, and contact lens (CL) surface microbiome.
Methods: In this prospective, cross-over study, experienced CL wearers (N=20) were randomized to wear a face mask for 6 hr/day (minimum) for a week or no mask for a week. The conjunctiva, eyelid, and CLs were then sampled.
A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc.
J Transl Med
May 2024
College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P.R. China.
Background: Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biological behaviors in GC. Emerging evidence suggests that several circRNAs derived from FNDC3B play pivotal roles in cancer.
View Article and Find Full Text PDFGut metabolomics and 16S rRNA sequencing analysis of the effects of arecoline on non-alcoholic fatty liver disease in rats.
Front Pharmacol
March 2023
Department of General Practice, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Non-alcoholic fatty liver disease (NAFLD) has gradually become the primary cause of fatty liver disease. Betel nuts have been used to treat gastrointestinal diseases. In the present study, we analyzed the pathology, serology, gut flora, and metabolites in a rat model of NAFLD, with and without betel nut alkaloid treatment, using an integrated approach involving pathology, serological testing, 16S rRNA gene sequencing, and ultra-performance liquid chromatography-mass spectrometry metabolomics.
View Article and Find Full Text PDFRibosomal RNA‑depleted RNA sequencing reveals the pathogenesis of refractory pneumonia in children.
Mol Med Rep
November 2021
Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Pneumonia caused by is a major cause of community‑acquired pneumonia in children. In some cases, pneumonia (MPP) can develop into refractory MPP (RMPP), which shows no clinical or radiological response to macrolides, and can progress to severe and complicated pneumonia. However, the pathogenesis of RMPP remains poorly understood.
View Article and Find Full Text PDFDifferential gene expression in a tripartite interaction: , and parasitic wasps.
PeerJ
March 2021
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Background: Several facultative bacterial symbionts of insects protect their hosts against natural enemies. strain Mel (hereafter ), a male-killing heritable symbiont of , confers protection against some species of parasitic wasps. Several lines of evidence suggest that -encoded ribosome inactivating proteins (RIPs) are involved in the protection mechanism, but the potential contribution of the fly-encoded functions (e.
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