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Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche.
Epigenetics
December 2023
Institute of Maternal and Child Research, School of Medicine, Universidad de Chile, Santiago, Chile.
Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome. Nevertheless, the link between early androgen excess and these risk factors remains unknown.
View Article and Find Full Text PDFSex differences in neurodevelopmental disorders.
Curr Opin Neurol
August 2019
Deakin University, Deakin Child Study Centre, School of Psychology, Burwood Campus, Victoria, Australia.
Purpose Of Review: There continues to be more males than females diagnosed with neurodevelopmental disorders, which may provide clues about their cause. This review will focus on the two most common neurodevelopmental disorders - autism spectrum disorder (autism) and attention deficit hyperactivity disorder (ADHD), and explore recent research to understand recent developments in the field.
Recent Findings: Biological mechanisms including genetics, hormones and their interaction with other risk factors, such as stress and lead exposure, point to complex causal pathways for neurodevelopmental disorders.
Body mass index at the presentation of premature adrenarche is associated with components of metabolic syndrome at puberty.
Eur J Pediatr
November 2018
Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Istanbul University, Capa, 34093, Istanbul, Turkey.
The aim of this study was to analyze the relationship between premature adrenarche (PA) and metabolic syndrome (MeS) parameters at presentation and during puberty. This study comprised 47 girls with PA. Age- and puberty-matched 22 healthy girls without PA were the control group.
View Article and Find Full Text PDFKlinefelter Syndrome. The Effects of Early Androgen Therapy on Competence and Behavioral Phenotype.
Sex Med Rev
October 2018
Department of Urology, Weill Cornell Medicine, New York, NY, USA; Consulting Research Services, Inc, North Bergen, NJ, USA. Electronic address:
Introduction: Klinefelter syndrome (KS) is the result of sex chromosome aneuploidy most often characterized as 47,XXY. The typical features of KS include tall stature, gynecomastia, small firm testicles, hypergonadotropic hypogonadism, and infertility. However, abnormalities in neurodevelopment, cognition, and social and behavioral functioning also can be present.
View Article and Find Full Text PDFMetabolic changes in patients with prostate cancer during androgen deprivation therapy.
Int J Urol
January 2018
Department of Urology, Tohoku University School of Medicine, Sendai, Japan.
Androgen deprivation therapy continues to be widely used for the treatment of prostate cancer despite the appearance of new-generation androgen-receptor targeting drugs after 2000. Androgen deprivation therapy can alleviate symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients, but it causes undesirable changes in lipid, glucose, muscle or bone metabolism. These metabolic changes could lead to new onset or worsening of diseases, such as obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, sarcopenia or fracture.
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