Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1148/83.2.228 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative analysis of the genomic and expression profiles of ANLN and KDR as prognostic markers in breast Cancer.
In Silico Pharmacol
January 2025
Department of Bioinformatics and Biostatistics, State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240 China.
Unlabelled: Breast cancer (BC) remains a highly heterogeneous disease, complicating diagnosis and treatment. This study investigates the prognostic significance of Anillin () and Kinase Insert Domain Receptor () genes, focusing on their mutational and expression landscapes in BC using data from The Cancer Genome Atlas (TCGA). We found that high expression is strongly associated with poor overall survival, highlighting its potential as a robust prognostic marker.
View Article and Find Full Text PDFDirect observation of small molecule activator binding to single PR65 protein.
NPJ Biosens
January 2025
Department of Electrical Engineering, University of Victoria, Victoria, BC V8W 3P6 Canada.
The reactivation of heterotrimeric protein phosphatase 2A (PP2A) through small molecule activators is of interest to therapeutic intervention due to its dysregulation, which is linked to chronic conditions. This study focuses on the PP2A scaffold subunit PR65 and a small molecule activator, ATUX-8385, designed to bind directly to this subunit. Using a label-free single-molecule approach with nanoaperture optical tweezers (NOT), we quantify its binding, obtaining a dissociation constant of 13.
View Article and Find Full Text PDFadapted to steppe-desert climate extremes one million years ago.
Commun Earth Environ
January 2025
University of Manitoba, Department of Earth Sciences, Winnipeg, MB Canada.
Questions about when early members of the genus adapted to extreme environments like deserts and rainforests have traditionally focused on . Here, we present multidisciplinary evidence from Engaji Nanyori in Tanzania's Oldupai Gorge, revealing that thrived in hyperarid landscapes one million years ago. Using biogeochemical analyses, precise chronometric dating, palaeoclimate simulations, biome modeling, fire history reconstructions, palaeobotanical studies, faunal assemblages, and archeological evidence, we reconstruct an environment dominated by semidesert shrubland.
View Article and Find Full Text PDFAn effective encryption approach using a combination of a non-chain ring and a four-dimensional chaotic map.
Cogn Neurodyn
December 2025
Department of Mathematics, Quaid-I-Azam University, Islamabad, Pakistan.
Algebraic structures are highly effective in designing symmetric key cryptosystems; however, if the key space is not sufficiently large, such systems become vulnerable to brute-force attacks. To address this challenge, our research focuses on enlarging the key space in symmetric key schemes by integrating the non-chain ring with a four-dimensional chaotic system. While chaotic maps offer significant potential for data processing, relying solely on them does not fully leverage their operational advantages.
View Article and Find Full Text PDFSurvey of the Aβ-peptide structural diversity: molecular dynamics approaches.
Biophys Rev
December 2024
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 119991 Moscow, Russia.
Unlabelled: The review deals with the application of Molecular Dynamics (MD) to the structure modeling of beta-amyloids (Aβ), currently classified as intrinsically disordered proteins (IDPs). In this review, we strive to relate the main advances in this area but specifically focus on the approaches and methodology. All relevant papers on the Aβ modeling are cited in the Tables in Supplementary Data, including a concise description of the applied approaches, sorted according to the types of the studied systems: modeling of the monomeric Aβ and Aβ aggregates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!