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Concurrent Fabry disease and IgA nephropathy in a patient with Crohn's disease: A case report.
Nephrology (Carlton)
January 2025
Department of Nephrology, Ajou University School of Medicine, Suwon, Republic of Korea.
Article Synopsis
- - A 27-year-old female with a decade-long history of Crohn's disease was diagnosed with both Fabry disease (FD) and IgA nephropathy (IgAN) after presenting with kidney issues, including microscopic hematuria and proteinuria.
- - Kidney biopsy results showed characteristics of IgAN, such as mesangial matrix widening, and electron microscopy revealed findings consistent with both IgAN and FD.
- - The diagnosis of FD was confirmed by low enzyme activity, leading to the start of enzyme replacement therapy; this case is notable as the first documented occurrence of FD, IgAN, and Crohn's disease coexisting in one patient.
Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Parasitol Int
February 2022
Laboratório de Imunomodulação e Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21045-900 Rio de Janeiro, Brazil. Electronic address:
Leishmaniasis chemotherapy is a bottleneck in disease treatment. Although available, chemotherapy is limited, toxic, painful, and does not lead to parasite clearance, with parasite resistance also being reported. Therefore, new therapeutic options are being investigated, such as plant-derived anti-parasitic compounds.
View Article and Find Full Text PDFRenal globotriaosylceramide deposits for Fabry disease linked to uncertain pathogenicity gene variant c.352C>T/p.Arg118Cys: A family study.
Mol Genet Genomic Med
November 2019
SICODIC, Ciudad de México, México.
Background: Fabry disease (FD) has an extensive phenotypic expression associated with GLA gene variants. The GLA gene variant c.352C>T/p.
View Article and Find Full Text PDFClinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum.
Hum Pathol
April 2019
Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Institute of Neuroscience, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address:
Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a recently recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of histologically typical MVNT: 6 were adults (mean age, 43.0 years [range, 23-56 years]) and 1 was a child (age, 10 years).
View Article and Find Full Text PDFPhysalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy.
Biomed Pharmacother
April 2016
Gonçalo Moniz Research Center-CPqGM/FIOCRUZ, Salvador, Bahia, Brazil; Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil. Electronic address:
Human T-lymphotropic virus type 1 (HTLV-1) induces a strong activation of the immune system, especially in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. The present study aimed to investigate the effects of physalin F on peripheral blood mononuclear cells (PBMC) of HAM/TSP subjects.
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