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| http://dx.doi.org/10.1136/adc.39.206.406 | DOI Listing |
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Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function.
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Department of Bioscience, University of Oslo, Oslo, Norway.
Perineuronal nets (PNNs) are a condensed form of extracellular matrix primarily found around parvalbumin-expressing (PV+) interneurons. The postnatal maturation of PV+ neurons is accompanied with the formation of PNNs and reduced plasticity. Alterations in PNN and PV+ neuron function have been described for mental disorders such as schizophrenia and autism.
View Article and Find Full Text PDFCAR-T cell targeting three receptors on autoreactive B cells for systemic lupus erythematosus therapy.
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Division of Haematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Pediatric Haematology and Oncology, The Angie Fowler Adolescent & Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA; The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated B cell activation, autoantibody production, and nephritis. B cell activating factor (BAFF) overexpression enhances autoreactive B-cell survival, driving autoimmunity. BAFF specific belimumab and CD20 specific rituximab antibodies are used for SLE therapy but are not curative, highlighting the need for alternative B cell depletion therapies.
View Article and Find Full Text PDFUnlabelled: The locus coeruleus (LC) is the primary source of noradrenaline (NA) in brain and its activity is essential for learning, memory, stress, arousal, and mood. LC-NA neuron activity varies over the sleep-wake cycle, with higher activity during wakefulness, correlating with increased CSF NA levels. Whether spontaneous and burst firing of LC-NA neurons during active and inactive periods is controlled by mechanisms independent of wakefulness and natural sleep, is currently unknown.
View Article and Find Full Text PDFBackbone resonance assignments of PhoCl, a photocleavable protein.
Biomol NMR Assign
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High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.
PhoCl is a photocleavable protein engineered from a green-to-red photoconvertible fluorescent protein by circular permutation, and has been used in various optogenetic applications including precise control of protein localization and activity in cells. Upon violet light illumination, PhoCl undergoes a β-elimination reaction to be cleaved at the chromophore, resulting in spontaneous dissociation into a large empty barrel and a small C-terminal peptide. However, the structural determinants and the mechanism of the PhoCl photocleavage remain elusive, hindering the further development of more robust photocleavable optogenetic tools.
View Article and Find Full Text PDFEfficient Hg(Ⅱ) removed by l-cysteine modified UiO-66 through chemical adsorption via a facile partial ligand replacement strategy.
J Colloid Interface Sci
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College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225000 PR China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing 210095 PR China; Institutes of Agricultural Science and Technology Development, Yangzhou 225127 Jiangsu, PR China.
In this work, UiO-66-l-cys with enhanced adsorption capacity for Hg(Ⅱ) in water was synthesized through a facile two-step partial ligand replacement strategy. The presence of the functional groups significantly enhanced the capacity of the material for Hg(Ⅱ). According to the Langmuir model, the maximum theoretical adsorption capacity was calculated to be 1321.
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