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Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions.
Inflammopharmacology
November 2024
Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí (UFPI), Universitaria Avenue, Teresina, Piauí, 64049-550, Brazil.
Acute, uncontrolled and/or long-lasting inflammation causes a breakdown in immunological tolerance, leading to chronicity and contributing to a series of significant local or systemic tissue changes. Anti-inflammatory efficacy, fewer adverse effects, improved selectivity, and curative action are imminent issues for patients suffering from chronic inflammation-related pathologies. Then, we performed a complete and critical review about anthelmintics, discussing the main classes and the available preclinical evidence on repurposing to treat inflammation-based conditions.
View Article and Find Full Text PDFMechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome.
Chin Med J Pulm Crit Care Med
June 2024
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Endothelial cells (ECs) form a semi-permeable barrier between the interior space of blood vessels and the underlying tissues. Pulmonary endothelial barrier integrity is maintained through coordinated cellular processes involving receptors, signaling molecules, junctional complexes, and protein-regulated cytoskeletal reorganization. In acute lung injury (ALI) or its more severe form acute respiratory distress syndrome (ARDS), the loss of endothelial barrier integrity secondary to endothelial dysfunction caused by severe pulmonary inflammation and/or infection leads to pulmonary edema and hypoxemia.
View Article and Find Full Text PDFRepeated doses of captopril induce airway hyperresponsiveness by modulating the TRPV1 receptor in rats.
Pulm Pharmacol Ther
September 2024
Department of Pharmacology, Federal University of Paraná, Brazil. Electronic address:
Although TRPV1 receptors play an essential role in the adverse effects on the airways following captopril treatment, there is no available evidence of their involvement in treatment regimens involving repeated doses of captopril. Comparing the difference in these two treatment regimens is essential since captopril is a continuous-use medication. Thus, this study explored the role of the transient receptor potential vanilloid 1 (TRPV1) in the effects of captopril on rat airways using two treatment regimens.
View Article and Find Full Text PDFCan essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?
Lipids Health Dis
April 2024
UND Life Sciences, 2221 NW 5th St, Battle ground, WA, 98604, USA.
It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including "long haul syndrome" are due to deficiency of essential fatty acids (EFAs) and dysregulation of their metabolism. This proposal is based on the observation that EFAs and their metabolites can modulate the swift immunostimulatory response of SARS-CoV-2 and similar enveloped viruses, suppress inappropriate cytokine release, possess cytoprotective action, modulate serotonin and bradykinin production and other neurotransmitters, inhibit NF-kB activation, regulate cGAS-STING pathway, modulate gut microbiota, inhibit platelet activation, regulate macrophage and leukocyte function, enhance wound healing and facilitate tissue regeneration and restore homeostasis. This implies that administration of EFAs could be of benefit in the prevention and management of COVID-19 and its associated complications.
View Article and Find Full Text PDFAerobic physical training reduces severe asthma phenotype involving kinins pathway.
Mol Biol Rep
April 2024
Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Avenida Ana Costa 95, Santos, SP, 11060-001, Brazil.
Article Synopsis
- Aerobic physical training (APT) has been shown to decrease eosinophilic airway inflammation in asthma, but its specific effects and mechanisms in severe cases are still not fully understood.
- The study involved both in vitro experiments with human cells related to asthma and in vivo experiments with mice to observe the impact of APT on inflammatory markers and cell activity.
- Results indicated that APT reduced various inflammatory cytokines and other immune cell activities, improved lung function, and increased levels of the anti-inflammatory molecule IL-10, indicating a potential therapeutic role in managing severe asthma.
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